| Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster. | |
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MedLine Citation:
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PMID: 6258818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The multistep synthesis and purification of 2,3,3',4,4',5-hexabromobiphenyl (HBBp) is described. Capillary gas chromatography revealed that HBBp comprises 0.05% of the industrial polybrominated biphenyl (PBB) mixture, fireMaster BP-6 (lot 7062). When administered to immature male Wistar rats, HBBp caused a dose-dependent increase in (a) the activity of benzo[a]pyrene (B[a]P) hydroxylase (AHH) and 4-chlorobiphenyl (4-CBP) hydroxylase and (b) the concentration of cytochrome P-450. Sodium dodecyl sulfate (SDS)-gel electrophoresis indicated that these increases in cytochrome P-450 and cytochrome P-450-dependent monooxygenase activities were accompanied by a dose-dependent intensification of a protein of relative molecular weight (Mr) 55 000 which comigrated with the major 3-methylcholanthrene(MC)-inducible form of cytochrome P-450 (i.e., cytochrome P-448). Like MC, but in contrast to phenobarbitone (PB), HBBp competitively displaced 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin ([3H]-TCDD) from the cytosolic protein thought to be the receptor for cytochrome P-448 induction. The results indicate that HBBp is a potent inducer of cytochrome P-448 and as such is the third MC-type inducer identified in fireMaster BP-6. |
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Authors:
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L W Robertson; A Parkinson; S Bandiera; S Safe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Chemico-biological interactions Volume: 35 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-05-26 Completed Date: 1981-05-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 13-24 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aryl Hydrocarbon Hydroxylases / biosynthesis Biphenyl Compounds / pharmacology* Cytochrome P-450 Enzyme System / metabolism Cytochromes / metabolism Enzyme Induction / drug effects* Flame Retardants / chemical synthesis, pharmacology* Male Methylcholanthrene / pharmacology Microsomes, Liver / enzymology* Phenobarbital / pharmacology Polybrominated Biphenyls / chemical synthesis, pharmacology* Rats Receptors, Aryl Hydrocarbon Receptors, Drug / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5 R01-CA21814-02)/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 0/Cytochromes; 0/Flame Retardants; 0/Polybrominated Biphenyls; 0/Receptors, Aryl Hydrocarbon; 0/Receptors, Drug; 50-06-6/Phenobarbital; 56-49-5/Methylcholanthrene; 59536-65-1/Firemaster BP-6; 77607-09-1/2,3,3',4,4',5-hexabromobiphenyl; 79682-25-0/2,3,3',4,4'5,6-heptabromobiphenyl; 9035-50-1/cytochrome P-448; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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