Document Detail

Potent genotoxicity of halogen lamps, compared to fluorescent light and sunlight.
MedLine Citation:
PMID:  2265469     Owner:  NLM     Status:  MEDLINE    
The light emitted by halogen lamps induced mutations in Salmonella typhimurium and DNA damage in Escherichia coli, as shown by the hypersensitivity of DNA repair-deficient strains. The mutagenicity of halogen lamps was considerably higher than that of fluorescent light and of sunlight, even at much lower illuminance levels. Excision mechanisms and SOS functions were involved in repairing light-induced base-pair substitutions and frameshift errors in bacterial DNA. At variance with solar irradiation, which produces mutagenic effects over a wide UV spectrum, genotoxicity of halogen lamps was almost exclusively due to far-UV wavelengths transmissible through UV-R-250 and UV-R-280 interference filters. The main mutagenic component of fluorescent light (254 nm) were almost 10(4)-fold more mutagenic than near-UV wavelengths (365 nm). All light sources exhibited some residual mutagenicity even following filtration through various cloths. On the other hand, appropriate glass or plastic covers consistently prevented mutagenic effects. This emphasizes the urgent need for a compulsory shielding of halogen and fluorescent lamps in order to prevent unnecessary exposures to genotoxic and potentially carcinogenic UV radiations.
S De Flora; A Camoirano; A Izzotti; C Bennicelli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  11     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-12     Completed Date:  1991-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2171-7     Citation Subset:  IM    
Institute of Hygiene and Preventive Medicine, University of Genoa, Italy.
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MeSH Terms
DNA Damage*
Escherichia coli / radiation effects
Light / adverse effects
Lighting / adverse effects*
Mutagenicity Tests
Salmonella typhimurium / radiation effects
Ultraviolet Rays / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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