| Potent aza-peptide derived inhibitors of HCV NS3 protease. | |
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MedLine Citation:
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PMID: 19596195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic hepatitis C infection is the primary cause for cirrhosis of the liver and hepatocellular carcinoma leading to liver failure and transplantation. The etiological agent hepatitis C virus produces a single positive strand RNA that is processed further with the help of NS3 serine protease to produce mature virus. Inhibition of this protease can potentially be used to develop drugs for HCV infections. Boceprevir is a ketoamide derived novel inhibitor of HCV NS3 protease that has been progressed to clinical trials and proven to be efficacious in humans. Herein, we report our efforts in identifying an aza-peptide derivative as a potential second generation compound, that lacks electrophilic ketoamide group and are potent in enzyme and replicon assay. |
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Authors:
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Srikanth Venkatraman; Wanli Wu; Neng-Yang Shih; F George Njoroge |
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Publication Detail:
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Type: Journal Article Date: 2009-06-17 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4760-3 Citation Subset: IM |
Affiliation:
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Schering Plough Research Institute, K15-MS 3545, Kenilworth, NJ 07033, United States. Srikanth.Venkatraman@spcorp.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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chemical synthesis,
chemistry*,
pharmacology Aza Compounds / chemical synthesis, chemistry*, pharmacology Hepacivirus / enzymology* Hepatitis C / drug therapy Humans Peptides / chemical synthesis, chemistry*, pharmacology Serine Proteinase Inhibitors / chemical synthesis, chemistry*, pharmacology Viral Nonstructural Proteins / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Aza Compounds; 0/NS3 protein, hepatitis C virus; 0/Peptides; 0/Serine Proteinase Inhibitors; 0/Viral Nonstructural Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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