| Potent antitumor actions of the new antibiotic boningmycin through induction of apoptosis and cellular senescence. | |
| | |
MedLine Citation:
|
PMID: 20948431 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Boningmycin, a new antibiotic of the bleomycin family, is isolated from the fermentation broth of Streptomyces verticillus var. pingyangensis n.sp. This study aimed to evaluate its antitumor actions and mechanism. The results showed that boningmycin exhibited potent inhibitory effects on several human solid tumor cells and that it was stronger than bleomycin. The administration of boningmycin inhibited the growth of human hepatoma HepG2 xenografts in nude mice, with more efficacy than that of bleomycin. Boningmycin led to an increase of the reactive oxygen species involving iron and caused G2/M phase accumulation in the HepG2 and human breast cancer MCF-7 cells. Two types of cell death, apoptosis and senescence, were detected after exposure to boningmycin. The accumulation of sub-G1 phase cells, an index of apoptosis, and the activation of caspase apoptotic pathways were detected after treatment with higher concentrations of boningmycin. Low concentrations of boningmycin led to a senescent phenotype with an increase in senescence-associated β-galactosidase activity and the time-dependent increase of p21, p27, and p53 expressions from 48 to120 h. Taken together, the results showed that boningmycin exhibits potent antitumor actions through the induction of apoptosis and cellular senescence. |
| | |
Authors:
|
Ning Gao; Boyang Shang; Xiumin Zhang; Cong Shen; Rong Xu; Hongzhang Xu; Ruxian Chen; Qiyang He |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anti-cancer drugs Volume: 22 ISSN: 1473-5741 ISO Abbreviation: Anticancer Drugs Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100823 Medline TA: Anticancer Drugs Country: England |
Other Details:
|
Languages: eng Pagination: 166-75 Citation Subset: IM |
Affiliation:
|
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
Next Document: Dose correspondence between olanzapine long-acting injection and oral olanzapine: recommendations fo...