| Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets. | |
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MedLine Citation:
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PMID: 20691130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactoferrin (LF), a multifunctional glycoprotein in mammalian milk, is reported to exert a modulatory effect on lipid metabolism. The aim of the present study was to elucidate whether enteric-coated LF (eLF) might improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. Using a double-blind, placebo-controlled design, Japanese men and women (n 26; aged 22-60 years) with abdominal obesity (BMI>25 kg/m2, and visceral fat area (VFA)>100 cm2) consumed eLF (300 mg/d as bovine LF) or placebo tablets for 8 weeks. Measurement of the total fat area, VFA and subcutaneous fat area from computed tomography images revealed a significant reduction in VFA ( - 14.6 cm2) in the eLF group, as compared with the placebo controls ( - 1.8 cm2; P = 0.009 by ANCOVA). Decreases in body weight, BMI and hip circumference in the eLF group ( - 1.5 kg, - 0.6 kg/m2, - 2.6 cm) were also found to be significantly greater than with the placebo (+1.0 kg, +0.3 kg/m2, - 0.2 cm; P = 0.032, 0.013, 0.041, respectively). There was also a tendency for a reduction in waist circumference in the eLF group ( - 4.4 cm) as compared with the placebo group ( - 0.9 cm; P = 0.073). No adverse effects of the eLF treatment were found with regard to blood lipid or biochemical parameters. From these results, eLF appears to be a promising agent for the control of visceral fat accumulation. |
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Authors:
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Tomoji Ono; Michiaki Murakoshi; Noriyuki Suzuki; Norio Iida; Motoyasu Ohdera; Masaaki Iigo; Toshihide Yoshida; Keikichi Sugiyama; Hoyoku Nishino |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-08-09 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1688-95 Citation Subset: IM |
Affiliation:
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Research and Development Headquarters, Lion Corporation, Odawara, Kanagawa, Japan. tomoono@lion.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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drug effects* Adult Anti-Obesity Agents / pharmacology, therapeutic use* Asian Continental Ancestry Group Body Mass Index Body Weight / drug effects* Double-Blind Method Female Hip / anatomy & histology Humans Intra-Abdominal Fat / drug effects*, metabolism Lactoferrin / pharmacology, therapeutic use* Male Middle Aged Obesity, Abdominal / drug therapy* Tablets, Enteric-Coated Tomography, X-Ray Computed Waist Circumference / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Lactoferrin; 0/Tablets, Enteric-Coated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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