Document Detail

Potassium treatment for hypertension in patients with high salt intake.
MedLine Citation:
PMID:  22541753     Owner:  NLM     Status:  Publisher    
Background: Previous metaanalyses of potassium supplementation in patients with hypertension observed little or no benefit, but failed to account the amount of salt intake. Objective: To assess the effect on blood pressure of potassium treatment in patients with high salt intake. Methods: We meta-analyzed studies of patient populations with both high salt and potassium intake. We searched Medline, Google, major journals, Pubmed. Publication bias, lack of heterogeneity, and lack of robustness were assessed using standard procedures for such purposes. Results: After the exclusion of 32 studies 10 studies were left in the meta-analysis. A pooled reduction of systolic blood pressure of -9.5 mmHg (95% confidence interval -10.8 to -8.1) and of diastolic blood pressure -6.4 mmHg (-7.3 to -5.6) was observed. These results were very heterogeneous (I2-values of 94 and 95%). After exclusion of single authored studies the results fell but remained statistically significant, -7.1 mmHg (-8.5 to -5.7), and -4.9 mmHg (-5.8 to -4.0). Heterogeneity of systolic blood pressure was no longer observed (I2-value 24.3%). Some publication bias was observed. Conclusions: 1. Potassium treatment reduces the blood pressure substantially in hypertensive patients with salt-rich diets. 2. The difference in magnitude of blood pressure reduction between different studies is probably related to the amount of salt intake. 3. Patients with reduced salt intake benefit little from potassium treatment. 4. Major meta-analyses published to date have severely underestimated the potential benefit of potassium treatment in patients with hypertension.
van Bommel; Ton Cleophas
Related Documents :
24751183 - Concordance of shape risk scale, a new pressure ulcer risk tool, with braden scale.
2149513 - Left ventricular hypertrophy reversal with labetalol and propranolol: a prospective ran...
16365123 - An equinus deformity of the ankle accounts for only a small amount of the increased for...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  -     ISSN:  0946-1965     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of intravenous midazolam limited sampling models to determine area under the concentratio...
Next Document:  The pharmacokinetics and pharmacodynamics of PF-00734200, a DPP-IV inhibitor, in healthy Japanese su...