Document Detail

Potassium transport and potassium channels in the kidney tubules.
MedLine Citation:
PMID:  9159639     Owner:  NLM     Status:  MEDLINE    
A variety of K+ channels have been identified using electrophysiological techniques including the patch-clamp method. The types of channels include inwardly-rectifying, ATP-dependent, Ca(2+)-dependent, voltage-gated, and so on. Some of them have been cloned by expression and/or PCR cloning techniques, which give us their amino-acid sequences and molecular topology in the cell membrane. Immunohistochemical studies have shown the proteins (channels) to be localized to the luminal and/or basolateral membranes of a certain nephron segment. However, the relationships of these proteins with the ionic channels identified functionally must be examined by their reconstitution in cell-free systems (lipid bilayer membrane) and/or their expression in cells lacking native K+ channels. Much more care should also be taken to avoid artifacts due to channel-inducing factors (CHIF). Structure-function studies at the molecular level will advance our knowledge of the renal K+ channels and provide us with a further understanding of the role of the kidney in K+ homeostasis.
K Kawahara; N Anzai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  47     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Physiology, Kitasato University School of Medicine, Sagamihara, Japan.
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MeSH Terms
Biological Transport
Kidney / metabolism
Kidney Tubules / metabolism*
Kidney Tubules, Collecting / metabolism
Loop of Henle / metabolism
Potassium / metabolism*
Potassium Channels
Reg. No./Substance:
0/Potassium Channels; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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