| Potassium-related inherited tubulopathies. | |
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MedLine Citation:
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PMID: 16810456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyper- and hypokalemia may carry severe clinical consequences. Different regulatory mechanisms, including the kidney, exert a tight regulation of plasma potassium levels. The renal pathway of potassium handling begins in the proximal tubule followed by the fine-tuning of its secretion or absorption at the distal tubule, including the thick ascending limb of Henle's loop, the distal convoluted tubule and the cortical collecting duct. Genetic studies in recent years have clarified the role of specific tubular channels and transporters in the pathogenesis of unique hyper- and hypokalemic tubulopathies, some of them non-hypertensive (pseudohypoaldosteronism, Bartter and Gitelman syndromes) and others hypertensive by definition (including Liddle and Gordon syndromes). This article reviews the genetic and clinical spectrum of hypokalemic and hyperkalemic tubulopathies. |
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Authors:
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D Landau |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 63 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2006-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1962-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics A, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva 84101, Israel. ldaniel@bgu.ac.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bartter Syndrome / genetics, metabolism Humans Hyperaldosteronism / metabolism Hyperkalemia / metabolism Hypertension / metabolism Hypokalemia / metabolism Infant Infant, Newborn Kidney Diseases / etiology*, genetics, metabolism Kidney Tubules* / metabolism Models, Biological Mutation Potassium / blood, metabolism* Receptors, Calcium-Sensing / genetics Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcium-Sensing; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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