| Potassium recycling in the renal medulla: effects of acute potassium chloride administration to rats fed a potassium-free diet. | |
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MedLine Citation:
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PMID: 7300124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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According to the hypothesis of potassium recycling in the renal medulla, a portion of potassium in fluid in the medullary collecting duct is reabsorbed, trapped in the medullary interstitium by countercurrent exchange, and secreted in either the pars recta or descending limb of the juxtamedullary nephron. To examine the effects of an acute change in potassium balance on recycling, we performed a micropuncture study on the exposed papilla of 8 chloride. A second group of 6 rats was studied under identical conditions and infused with potassium chloride and amiloride. In the first group, the fraction of filtered potassium remaining at the end of the juxtamedullary descending limb increased with time to values over 100% concomitantly with the rise in urinary excretion of potassium. A strong association was found between those two variables (P less than 0.025). In the second group, in which the increase in urinary fractional excretion of potassium was prevented by amiloride, the rise in fractional of filtered potassium remaining at the end of the juxtamedullary nephron was abolished. These findings are interpreted as providing further support for the hypothesis of medullary recycling of potassium. |
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Authors:
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J F Arrascue; D C Dobyan; R L Jamison |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Kidney international Volume: 20 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1982-01-20 Completed Date: 1982-01-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 348-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiloride
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pharmacology Animals Diet* Female Kidney Medulla / metabolism* Male Potassium / metabolism*, urine Potassium Chloride / administration & dosage* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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AM 05741-01/AM/NIADDK NIH HHS; AM 18077/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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2609-46-3/Amiloride; 7440-09-7/Potassium; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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