Document Detail


Potassium nitrite reaction with 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine in relation to the drug screening analysis.
MedLine Citation:
PMID:  10486947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently potassium nitrite has been used as an adulterant to interfere with the analysis of 11-nor-delta 9-tetrahydro-cannabinol-9-carboxylic acid (THC-COOH) in urine. A comprehensive study of the THC-COOH and nitrite reaction chemistry and stability under various conditions is presented. Reverse phase high performance liquid chromatography (HPLC) and negative electrospray mass spectrometry (ESMS) results are given to substantiate the derived reaction mechanism and properties leading to reaction termination. The addition of potassium carbonate as a buffering agent prior to or following sample void as a means of preventing the formation of a nitroso-complexed form of the 11-nor-delta 9+-tetrahydrocannabinol-9-carboxylic acid is evaluated.
Authors:
S A Lewis; L A Lewis; A Tuinman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  44     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-5     Citation Subset:  IM    
Affiliation:
Analytical Services Organization, Lockheed Martin Energy Systems, Inc., Oak Ridge, TN 37831-8244, USA.
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MeSH Terms
Descriptor/Qualifier:
Carbonates / administration & dosage
Chromatography, High Pressure Liquid
Drug Contamination*
Drug Interactions
Forensic Medicine / methods*
Humans
Marijuana Abuse / urine*
Mass Spectrometry
Nitrites / urine*
Potassium / administration & dosage
Substance Abuse Detection / methods*
Tetrahydrocannabinol / analogs & derivatives*,  urine
Chemical
Reg. No./Substance:
0/Carbonates; 0/Nitrites; 1972-08-3/Tetrahydrocannabinol; 584-08-7/potassium carbonate; 64280-14-4/11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; 7440-09-7/Potassium; 7758-09-0/potassium nitrite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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