| Potassium nitrite reaction with 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine in relation to the drug screening analysis. | |
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MedLine Citation:
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PMID: 10486947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently potassium nitrite has been used as an adulterant to interfere with the analysis of 11-nor-delta 9-tetrahydro-cannabinol-9-carboxylic acid (THC-COOH) in urine. A comprehensive study of the THC-COOH and nitrite reaction chemistry and stability under various conditions is presented. Reverse phase high performance liquid chromatography (HPLC) and negative electrospray mass spectrometry (ESMS) results are given to substantiate the derived reaction mechanism and properties leading to reaction termination. The addition of potassium carbonate as a buffering agent prior to or following sample void as a means of preventing the formation of a nitroso-complexed form of the 11-nor-delta 9+-tetrahydrocannabinol-9-carboxylic acid is evaluated. |
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Authors:
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S A Lewis; L A Lewis; A Tuinman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of forensic sciences Volume: 44 ISSN: 0022-1198 ISO Abbreviation: J. Forensic Sci. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375370 Medline TA: J Forensic Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 951-5 Citation Subset: IM |
Affiliation:
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Analytical Services Organization, Lockheed Martin Energy Systems, Inc., Oak Ridge, TN 37831-8244, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbonates
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administration & dosage Chromatography, High Pressure Liquid Drug Contamination* Drug Interactions Forensic Medicine / methods* Humans Marijuana Abuse / urine* Mass Spectrometry Nitrites / urine* Potassium / administration & dosage Substance Abuse Detection / methods* Tetrahydrocannabinol / analogs & derivatives*, urine |
| Chemical | |
Reg. No./Substance:
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0/Carbonates; 0/Nitrites; 1972-08-3/Tetrahydrocannabinol; 584-08-7/potassium carbonate; 64280-14-4/11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; 7440-09-7/Potassium; 7758-09-0/potassium nitrite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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