Document Detail

Potassium loss associated with hydrochlorothiazide versus chlorthalidone.
MedLine Citation:
PMID:  7332917     Owner:  NLM     Status:  MEDLINE    
A retrospective survey using chart review was conducted to determine the incidence of clinically significant hypokalemia resulting from therapy with chlorthalidone (CTLD) or hydrochlorothiazide (HCTZ). The frequency of hypokalemia, potassium less than or equal to 3.0 mEq/liter, was 4/29 patients (13.8%) in the CTLD once-daily group, 0/17 in the HCDL twice-daily group, and 0/31 in the HCTZ once-daily group. Using the Fisher exact probability test, a significant difference in the incidence of hypokalemia was observed between the CTLD once-daily and HCTZ once-daily groups. From the results, it is apparent that a diuretic's duration of actions, as represented by HCTZ (short-acting) and CTLD (long-acting), influences serum potassium concentrations; CTLD produced a greater incidence and degree of hypokalemia.
L Sumiye; A S Vivian; K B Frisof; E C Podany
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  4     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-20     Citation Subset:  IM    
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MeSH Terms
Chlorothiazide / adverse effects*,  therapeutic use
Chlorthalidone / adverse effects*,  therapeutic use
Dose-Response Relationship, Drug
Hypertension / drug therapy
Hypokalemia / chemically induced*
Middle Aged
Retrospective Studies
Reg. No./Substance:
58-94-6/Chlorothiazide; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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