Document Detail

Potassium-induced renal loss of sodium in lithium-treated rats.
MedLine Citation:
PMID:  6987825     Owner:  NLM     Status:  MEDLINE    
A high intake of potassium prevents lithium-induced renal water and sodium losing conditions. In order to investigate a probable curative effect of potassium against these conditions Wistar rats were given lithium by the food (80 mmol/kg). The animals had access to water and a 0.46 M NaCl solution. The potassium content of the food was 100 mmol/kg during the pretreatment period of about 4 weeks, then 500 mmol of KCl per kg food was added. Potassium administration did not significantly influence the intake of water but led to a temporary rise of the intake of 0.46 M NaCl. The intake rose from 100 mu to 500 mumol/hr/100 g body weight in the course of 2-3 days and then gradually declined during three weeks. The increase of the sodium intake was not superfluous but due to a renal loss of sodium. If the animals were not allowed to replace the lost sodium by drinking more NaCl solution, plasma renin rose, body weight, lithium clearance, and water intake fell. It is concluded that a high potassium intake was unable to cure lithium-induced water and sodium losing conditions in rats. Prolonged lithium administration interferes with the mechanism for selective renal excretion of potassium. A high potassium intake resulted in a temporary renal loss of sodium.
O V Olesen; K Thomsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  46     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  178-84     Citation Subset:  IM    
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MeSH Terms
Body Water / metabolism*
Body Weight / drug effects
Drinking / drug effects
Kidney / metabolism*
Lithium / antagonists & inhibitors,  metabolism,  pharmacology*
Potassium / metabolism,  pharmacology*,  therapeutic use
Renin / blood
Sodium / metabolism*
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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