| Potassium in hemorrhagic shock: a potential marker of tissue hypoxia. | |
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MedLine Citation:
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PMID: 20539177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study was designed to evaluate serum potassium level variation in a porcine model of hemorrhagic shock (HS). METHODS: Eight pigs were studied in a controlled hemorrhage model of HS. Blood withdrawal began at a 50 mL/min to 70 mL/min rate, adjusted to reach a mean arterial pressure (MAP) level of 60 mm Hg in 10 minutes. When MAP reached 60 mm Hg, the blood withdrawal rate was adjusted to maintain a MAP decrease rate of 10 mm Hg every 2 minutes to 4 minutes. Arterial and mixed venous blood samples were collected at MAP levels of 60 mm Hg, 50 mm Hg, 40 mm Hg, 30 mm Hg, 20 mm Hg, and 10 mm Hg and analyzed for oxygen saturation, Po2, Pco2, potassium, lactate, bicarbonate, hemoglobin, pH, and standard base excess. RESULTS: Significant increase in serum potassium occurred early in all animals. The rate of rise in serum potassium and its levels accompanied the hemodynamic deterioration. Hyperkalemia (K >5 mmol/L) incidence was 12.5% at 60 mm Hg and 50 mm Hg, 62.5% at 40 mm Hg, 87.5% at 30 mm Hg, and 100% at 20 mm Hg. Strong correlations were found between potassium levels and lactate (R = 0.82), SvO2 (R = 0.87), DeltapH (R = 0.83), and DeltaPco2 (R = 0.82). CONCLUSIONS: Serum potassium increase accompanies the onset of HS. The rise in serum potassium was directly related to the hemodynamic deterioration of HS and strongly correlated with markers of tissue hypoxia. |
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Authors:
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Joel Avancini Rocha Filho; Ricardo S Nani; Luiz A C D'Albuquerque; Luíz M S Malbouisson; Maria J C Carmona; Mauricio Rocha-E-Silva; José O C Auler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 68 ISSN: 1529-8809 ISO Abbreviation: J Trauma Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-07-15 Revised Date: 2010-10-18 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 1335-41 Citation Subset: AIM; IM |
Affiliation:
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Divisão de Anestesia, Hospital das Clínicas da Faculdade de Medicina da USP, Avenida Dr. Enéas de Carvalho Aguiar, São Paulo, SP, Brazil. joelrocha@me.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anoxia / blood* Biological Markers / blood Humans Hyperkalemia / blood Male Potassium / blood* Shock, Hemorrhagic / blood* Swine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 7440-09-7/Potassium |
| Comments/Corrections | |
Comment In:
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J Trauma. 2010 Oct;69(4):1004-5; author reply 1005
[PMID:
20938299
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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