Document Detail

Potassium efflux from the myocardium during hypoxia: role of lactate ions.
MedLine Citation:
PMID:  3455355     Owner:  NLM     Status:  MEDLINE    
To determine the role of lactate in the causation of potassium efflux during hypoxia, the effect of lactate ions on the uptake and efflux of 42potassium was studied in the isolated arterially perfused interventricular septum of the rabbit. Septa were equilibrated with lactate (50 mmol.litre-1) under isosmotic conditions before switching to a perfusate containing the inert and impermeant anion isethionate (50 mmol.litre-1). A reduction in tissue 42potassium content was detected, which could only partly be accounted for by increased efflux. During hypoxic substrate free perfusion potassium loss was due to an increased efflux with no evidence of altered influx. The extrusion of accumulating anions, such as lactate ions, from the myocardium is one mechanism for the early potassium loss during hypoxia.
T Crake; M S Kirby; P A Poole-Wilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  21     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-10-27     Completed Date:  1988-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  886-91     Citation Subset:  IM    
Cardiothoracic Institute, London.
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MeSH Terms
Anoxia / metabolism*
Lactates / metabolism*
Myocardium / metabolism*
Osmolar Concentration
Potassium / metabolism*
Sodium / metabolism
Time Factors
Reg. No./Substance:
0/Lactates; 7440-09-7/Potassium; 7440-23-5/Sodium

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