Document Detail


Potassium channels and uterine vascular adaptation to pregnancy and chronic hypoxia.
MedLine Citation:
PMID:  24063385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a normal course of pregnancy, uterine vascular tone is significantly decreased resulting in a striking increase in uterine blood flow, which is essential for fetal development and fetal growth. Chronic hypoxia during gestation may adversely affect the normal adaptation of uterine vascular tone and increase the risk of preeclampsia and fetal intrauterine growth restriction. In this review, we present evidence that the regulation of K+ channels is an important mechanism in the adaptation of uterine vascular tone to pregnancy and hypoxia. There are four types of K+ channels identified in arterial smooth muscle cells: 1) voltage-dependent K(+) (Kv) channels, 2) Ca2+-activated K(+) (KCa) channels, 3) inward rectifier K(+) (KIR) channels, and 4) ATP-sensitive K(+) (KATP) channels. Pregnancy differentially augments the expression and activity of K(+) channels via downregulation of protein kinase C signaling in uterine and other vascular beds, leading to decreased uterine vascular tone and increased uterine blood flow. Sex steroid hormones play an important role in the pregnancy- mediated alteration of K+ channels in the uterine vasculature. In addition, chronic hypoxia alters uterine vascular K(+) channels expression and activities via modulation of steroid hormones/receptors-mediated signaling, resulting in increased uterine vascular tone during pregnancy.
Authors:
Ronghui Zhu; DaLiao Xiao; Lubo Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current vascular pharmacology     Volume:  11     ISSN:  1875-6212     ISO Abbreviation:  Curr Vasc Pharmacol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-25     Completed Date:  2014-04-24     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  737-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Animals
Anoxia / metabolism,  physiopathology*
Female
Humans
Placental Circulation / physiology*
Potassium Channels / metabolism*
Pregnancy
Uterus / blood supply*,  metabolism
Grant Support
ID/Acronym/Agency:
DA032510/DA/NIDA NIH HHS; HD031226/HD/NICHD NIH HHS; HL054094/HL/NHLBI NIH HHS; HL057787/HL/NHLBI NIH HHS; HL089012/HL/NHLBI NIH HHS; HL110125/HL/NHLBI NIH HHS; R01 HL110125/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Potassium Channels
Comments/Corrections

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