Document Detail


Potassium channels in hypokalaemic periodic paralysis: a key to the pathogenesis?
MedLine Citation:
PMID:  8403805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. A possible role for the ATP-sensitive potassium channels in the pathogenesis of hypokalaemic periodic paralysis was investigated. 2. We assessed insulin release and muscle strength after intravenous glucose loading with and without the potassium channel opener pinacidil and the potassium channel blocker glibenclamide in three patients with hypokalaemic periodic paralysis and in a pair of matched control subjects for each patient. 3. A significantly higher initial insulin response (1.5-30 min) was found in the patients with hypokalaemic periodic paralysis in comparison with the control subjects. During potassium channel blocking with glibenclamide the insulin release was more enhanced in patients than in control subjects. On the other hand, the potassium channel opener pinacidil impaired the insulin release in healthy control subjects but not in patients. The serum glucose levels showed no differences between patients and control subjects. In one of the patients with hypokalaemic periodic paralysis glucose loading resulted in a fall in muscle strength, which did not occur during the administration of pinacidil. 4. These findings suggest a disturbance in the ATP-sensitive potassium channel in patients with hypokalaemic periodic paralysis, which is not limited to pancreatic beta cells, but may be also involved in the abnormal behaviour of skeletal muscle.
Authors:
T P Links; A J Smit; H J Oosterhuis; W D Reitsma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  85     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-25     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Female
Glucose / diagnostic use
Glyburide / pharmacology
Guanidines / pharmacology
Humans
Hypokalemia / etiology,  metabolism*
Insulin / blood*
Male
Muscles / drug effects,  physiology
Paralyses, Familial Periodic / complications,  metabolism*
Pinacidil
Potassium Channels / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Guanidines; 0/Potassium Channels; 10238-21-8/Glyburide; 11061-68-0/Insulin; 50-99-7/Glucose; 85371-64-8/Pinacidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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