| Potassium channels are a new target field in anticancer drug design. | |
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MedLine Citation:
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PMID: 18221064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Potassium channels constitute a large and heterogeneous family with more than eighty genes which encode membrane proteins that control membrane potential. In addition to nerve and cardiac action potential, these proteins are involved in a number of physiological processes including volume regulation, apoptosis, immunomodulation and differentiation. Many potassium channels have been related to proliferation and cell-cycle progression in mammalian cell lines and certain potassium channels show impaired expression in cancer cells and tumours. In addition, in some cases a correlation has been established between the protein expression levels and the grade of malignancy of the tumour. Many drugs have been found to inhibit both K+ channel activity and cell-cycle progression. Since potassium channels may play a pivotal role in tumour cell proliferation, these proteins should be taken into account when designing new cancer treatment strategies. The increasing list of recent patents, covered in this review, shows the relevance of this emergent subject. |
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Authors:
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Nuria Villalonga; Joan C Ferreres; Josep M Argilés; Enric Condom; Antonio Felipe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Recent patents on anti-cancer drug discovery Volume: 2 ISSN: 1574-8928 ISO Abbreviation: Recent Pat Anticancer Drug Discov Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-02-14 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 101266081 Medline TA: Recent Pat Anticancer Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 212-23 Citation Subset: IM |
Affiliation:
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Molecular Physiology Laboratory, Departament de Bioquímica i Biologia Molecular de la Facultat de Biologia, Universitat de Barcelona. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemistry*, pharmacology* Cell Proliferation / drug effects Drug Design Humans Neoplasms / drug therapy*, metabolism*, pathology Patents as Topic Potassium Channel Blockers / pharmacology Potassium Channels / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Potassium Channel Blockers; 0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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