| Potassium channel stimulation in normal subjects and in patients with essential hypertension: an acute study with cromakalim (BRL 34915). | |
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MedLine Citation:
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PMID: 2698941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the acute effects of the potassium channel opener cromakalim on blood pressure, the renin-angiotensin-aldosterone system and renal function in eight patients with essential hypertension and five normal subjects. In the hypertensive patients, blood pressure decreased significantly from 2 to 6 h after treatment with cromakalim 1.5 mg compared with placebo, but was unchanged in the normotensives. In both groups, the heart rate and plasma renin activity increased after the administration of cromakalim compared with placebo; however, plasma aldosterone was unchanged. There was no significant change in urinary electrolyte excretion in either group; urine flow decreased after the administration of cromakalim compared with placebo in normal subjects, but not in patients with essential hypertension. Cromakalim lowers blood pressure acutely in patients with essential hypertension but not in normotensive subjects. This may be due to a greater reflex response in the normal subjects or to specific effects of cromakalim on mechanisms causing the high blood pressure. |
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Authors:
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D R Singer; N D Markandu; M A Miller; A L Sugden; G A MacGregor |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 7 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S294-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Charing Cross and Westminster Medical School, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Benzopyrans / therapeutic use* Blood Pressure / drug effects, physiology Cromakalim Double-Blind Method Female Humans Hypertension / drug therapy*, physiopathology Kidney / drug effects, physiopathology Male Middle Aged Potassium Channels / drug effects*, physiology Pyrroles / therapeutic use* Randomized Controlled Trials as Topic Renin-Angiotensin System / drug effects, physiology Stimulation, Chemical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzopyrans; 0/Potassium Channels; 0/Pyrroles; 94470-67-4/Cromakalim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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