Document Detail

Potassium channel openers: are they effective as pretreatment or additives to cardioplegia?
MedLine Citation:
PMID:  10881806     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to test the hypothesis that the potassium channel opener pinacidil (Pin) as a pretreatment (PT) agent or additive to St. Thomas' solution (StT) could enhance myocardial protection. METHODS: In a parabiotic rabbit Langendorff model, 36 hearts underwent global normothermic ischemia (1 hour) followed by reperfusion (30 minutes). Cardioplegia (50 mL, every 20 minutes) consisted of: StT; PinPT/StT, where Pin PT preceded StT arrest; Pin alone; Pin in StT (Pin/StT); and Pin in low potassium StT. Systolic function after reperfusion (percent recovery of developed pressure) and compliance (diastolic slope from pressure-volume relationship) were measured. RESULTS: There was no significant difference between StT and PinPT/StT in percent recovery of developed pressure (51.54% +/- 3.5%, 42.17% +/- 4.0%, respectively) or compliance. Likewise, no significant differences occurred between Pin, StT, Pin/StT, and Pin in low potassium StT in percent recovery of developed pressure (58.99% +/- 4.8%, 51.54% +/- 3.5%, 53.09% +/- 3.2%, 66.43% +/- 7.3%, respectively) or compliance. CONCLUSIONS: Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery.
C T Ducko; E R Stephenson; A M Jayawant; D W Vigilance; R J Damiano
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  69     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1363-8     Citation Subset:  AIM; IM    
Department of Surgery, The Milton S. Hershey Medical Center, Penn State Geisinger Health System, Hershey, Pennsylvania, USA.
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MeSH Terms
Bicarbonates / therapeutic use
Calcium Chloride / therapeutic use
Cardioplegic Solutions / therapeutic use*
Coronary Circulation / drug effects
Magnesium / therapeutic use
Pinacidil / pharmacology,  therapeutic use*
Potassium Channels / drug effects*
Potassium Chloride / therapeutic use
Reperfusion Injury / prevention & control
Sodium Chloride / therapeutic use
Grant Support
Reg. No./Substance:
0/Bicarbonates; 0/Cardioplegic Solutions; 0/Potassium Channels; 0/St. Thomas' Hospital cardioplegic solution; 10043-52-4/Calcium Chloride; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; 85371-64-8/Pinacidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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