Document Detail

Potassium channel mechanics.
MedLine Citation:
PMID:  11719196     Owner:  NLM     Status:  MEDLINE    
What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
F J Sigworth
Related Documents :
15799976 - Identification of a novel pharmacophore for peptide toxins interacting with k+ channels.
9457476 - Voltage-activated potassium channels in mammalian neurons and their block by novel phar...
10733966 - Mutation in pore domain uncovers cation- and voltage-sensitive recovery from inactivati...
16506886 - A cell-sparing electric field stimulation technique for high-throughput screening of vo...
9325366 - Calcium-activated cation nonselective current contributes to the fast afterdepolarizati...
7921616 - The influence of acetazolamide and amlodipine on the intracellular sodium content of ra...
Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  32     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-01-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  555-6     Citation Subset:  IM    
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ion Channel Gating / physiology*
Neurons / physiology*
Potassium Channels / genetics*,  metabolism*
Reg. No./Substance:
0/Potassium Channels
Comment On:
Neuron. 2001 Nov 20;32(4):649-56   [PMID:  11719205 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Do NMDA receptor kinetics regulate the end of critical periods of plasticity?
Next Document:  Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity.