Document Detail


Potassium channel mechanics.
MedLine Citation:
PMID:  11719196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
Authors:
F J Sigworth
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  32     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-01-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  555-6     Citation Subset:  IM    
Affiliation:
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ion Channel Gating / physiology*
Mutagenesis
Neurons / physiology*
Potassium Channels / genetics*,  metabolism*
Chemical
Reg. No./Substance:
0/Potassium Channels
Comments/Corrections
Comment On:
Neuron. 2001 Nov 20;32(4):649-56   [PMID:  11719205 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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