| Potassium balance and ouabain binding sites in intact porcine hearts during isoproterenol infusion. | |
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MedLine Citation:
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PMID: 3992054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pacing-induced tachycardia causes a net loss of K+ from the myocardium whereas adrenergic stimulation at constant heart rate will cause a net K+ accumulation. In the intact heart, isoproterenol (ISO) will, as expected, exert both effects, but the net result with regard to K+ balance is unknown. In the experiments on intact porcine hearts presented herein, a shunt from the coronary sinus to the right atrium allowed continuous monitoring of the myocardial K+ balance. ISO caused heart rate, dP/dt, and peak aortic flow to increase to a new steady state in less than 10 sec. There was an initial K+ loss lasting 1 min followed by a 10- to 15-times larger net uptake subsiding after 7 min. Overall, tissue K+ increased by 140.5 +/- 60.0 mumole/100 g, corresponding roughly to a 3 mM increase in intracellular concentration during ISO infusion. Ouabain binding sites determined in intact biopsies from the left ventricle remained unchanged. Thus, ISO has a biphasic effect on myocardial K+ balance, eventually causing a net increase of tissue K+ content probably unrelated to the inotropic effects. Direct stimulation of the Na+, K+-ATPase without changing the number of enzymes is possible. |
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Authors:
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O M Sejersted; F R Andersen; A Ilebekk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in myocardiology Volume: 6 ISSN: 0270-4056 ISO Abbreviation: Adv Myocardiol Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-14 Completed Date: 1985-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000285 Medline TA: Adv Myocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial Female Heart / drug effects* Heart Ventricles / drug effects Hemodynamics / drug effects Isoproterenol / pharmacology* Kinetics Male Myocardium / metabolism* Ouabain / metabolism Potassium / metabolism* Receptors, Drug / drug effects*, metabolism Sodium / metabolism Sodium-Potassium-Exchanging ATPase* Swine |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Drug; 0/cardiac glycoside receptors; 630-60-4/Ouabain; 7440-09-7/Potassium; 7440-23-5/Sodium; 7683-59-2/Isoproterenol; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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