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POSTURAL PREPARATION PRIOR TO STEPPING IN PATIENTS WITH PARKINSON'S DISEASE.
MedLine Citation:
PMID:  21525376     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
People with Parkinson's disease (PD) frequently have difficulties with generating anticipatory postural adjustments (APAs) for forward propulsion and lateral weight transfer when initiating gait. This impairment has been attributed to deficits in motor planning and preparation. This study examined the preparation of APAs prior to an imperative cue to initiate forward stepping. A startling acoustic stimulus (SAS) was used to probe the state of preparation of the APAs in 8 PD (off medication) and 7 matched Control subjects. Subjects performed visually cued trials involving a pre-cue light instructing them to prepare to step, followed 3.5 seconds later by a go-cue light to rapidly initiate stepping. In random trials, a SAS (124 dB) was presented at -1500, -1000, -500, -250, -100, or 0 ms before the go-cue. Subjects also performed self-initiated steps. Ground reaction forces (GRFs), center of pressure (CoP) changes, and electromyographic (EMG) signals were recorded. The SAS triggered APAs in 94 (± 11%) (PD) and 96 (± 8%) (Controls) of trials at latencies 89 (± 4 ms) (PD) and 97 (± 3 ms) (Controls) earlier than Control trials.The temporal profile of APA preparation was similar between groups. However, peak EMG, GRF, and medio-lateral CoP amplitudes were reduced in PD. SAS-evoked APAs at 0 ms matched Control trial APAs and were enhanced compared with self-initiated stepping. These results demonstrate that people with mild to moderate PD can plan and prepare the appropriate APA sequence prior to the expected cue to initiate gait, however, the prepared APAs are underscaled in magnitude.
Authors:
Mark W Rogers; Robert Kennedy; Sonia Palmer; Monika Pawar; Maggie Reising; Katherine M Martinez; Tanya Simuni; Yunhui Zhang; Colum D Mackinnon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-27
Journal Detail:
Title:  Journal of neurophysiology     Volume:  -     ISSN:  1522-1598     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1University of Maryland.
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