| Postural deformities in Parkinson's disease. | |
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MedLine Citation:
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PMID: 21514890 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Postural deformities are frequent and disabling complications of Parkinson's disease (PD) and atypical parkinsonism. These deformities include camptocormia, antecollis, Pisa syndrome, and scoliosis. Recognition of specific postural syndromes might have differential diagnostic value in patients presenting with parkinsonism. The evidence to date suggests that postural deformities have a multifactorial pathophysiology. Contributing factors include muscular rigidity; axial dystonia; weakness caused by myopathy; body scheme defects due to centrally impaired proprioception; and structural changes in the spine. The relative contribution of these different factors varies between patients and across specific syndromes. Improved understanding of the mechanisms underlying postural deformities in PD might ultimately lead us to more effective management strategies for these disabling and drug-refractory complications. |
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Authors:
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Karen M Doherty; Bart P van de Warrenburg; Maria Cecilia Peralta; Laura Silveira-Moriyama; Jean-Philippe Azulay; Oscar S Gershanik; Bastiaan R Bloem |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Lancet neurology Volume: - ISSN: 1474-4465 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Reta Lila Institute of Neurological studies, UCL Institute of Neurology, Queen Square, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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