| Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. | |
| | |
MedLine Citation:
|
PMID: 19341715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study has examined the anticonvulsant and neuroprotective effect of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC), a selective agonist for group II metabotropic glutamate receptors (mGluRs) when given 10-15 min after the onset of seizures induced in 12-day-old rats by bilateral icv infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side). For biochemical analyses, rat pups were sacrificed during generalized clonic-tonic seizures, approximately 45-50 min after infusion of DL-HCA. Comparable time intervals were used for sacrificing the animals which received 2R,4R-APDC (0.05 nmol/side) or saline. The severity of seizures was influenced only slightly when the agonist was given after the onset of seizures, as evaluated both from the behavioral symptoms and from EEG recordings. A tendency to lower number and a shorter duration of seizures was outlined in animals posttreated with 2R,4R-APDC, but the differences did not reach the level of statistical significance. Cortical energy metabolite changes which normally accompany seizures in immature rats (large decrease of glucose and glycogen and a marked rise of lactate) were ameliorated only partially. The neuroprotective effect of 2R,4R-APDC was evaluated after 24 h and 6 days of survival following DL-HCA-induced seizures. Massive neuronal degeneration in many brain regions, mainly in the hippocampus and thalamus, following infusion of DL-HCA alone was only partially attenuated after 2R,4R-APDC posttreatment. The present findings clearly indicate that both anticonvulsant and neuroprotective effect of 2R,4R-APDC against DL-HCA-induced seizures is substantially diminished when the agonist is given after the onset of seizures as compared with its efficacy after the pretreatment (Exp. Neurol.192, 420-436, 2005). |
| | |
Authors:
|
Jaroslava Folbergrová; Rastislav Druga; Grygoriy Tsenov; Renata Haugvicová; Jakub Otáhal |
Related Documents
:
|
3675085 - Influence of clonazepam on electrocorticographic changes induced by metrazol in rats du... 15582835 - Cognitive impairment following status epilepticus and recurrent seizures during early d... 9698055 - Ontogeny of ethosuximide action against two seizure models in rats is different. 8415825 - Arrest of seizure series induced by an intracortical injection of penicillin in the awa... 8946485 - Influence of early postnatal gonadal hormones on anxiety in adult male rats. 570505 - Dopaminergic antagonism and catalepsy in the developing rat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-31 |
Journal Detail:
|
Title: Brain research Volume: 1273 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-26 Completed Date: 2009-08-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 144-54 Citation Subset: IM |
Affiliation:
|
Institute of Physiology, v.v.i., Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic. folbergr@biomed.cas.cz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
metabolism Animals Brain / drug effects*, growth & development, metabolism Convulsants / pharmacology Cytoprotection / drug effects, physiology Drug Administration Schedule Drug Interactions / physiology Epilepsy / drug therapy*, metabolism, physiopathology Excitatory Amino Acid Agonists / therapeutic use* Hippocampus / drug effects, growth & development, metabolism Homocysteine / analogs & derivatives, pharmacology Male Nerve Degeneration / chemically induced, physiopathology, prevention & control Neuroprotective Agents / therapeutic use* Proline / analogs & derivatives*, therapeutic use Rats Rats, Wistar Receptors, Metabotropic Glutamate / agonists*, metabolism Thalamus / drug effects, growth & development, metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/4-aminopyrrolidine-2,4-dicarboxylic acid; 0/Convulsants; 0/Excitatory Amino Acid Agonists; 0/Neuroprotective Agents; 0/Receptors, Metabotropic Glutamate; 0/metabotropic glutamate receptor 2; 1001-13-4/homocysteic acid; 147-85-3/Proline; 454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signa...
Next Document: The search for a pathophysiological link between gender, cardiac endocrine function, body mass regul...