Document Detail


Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression.
MedLine Citation:
PMID:  23893768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Genetics of Recurrent Early-Onset Depression study (GenRED II) data were used to examine the relationship between posttraumatic stress disorder (PTSD) and attempted suicide in a population of 1,433 individuals with recurrent early-onset major depressive disorder (MDD). We tested the hypothesis that PTSD resulting from assaultive trauma increases risk for attempted suicide among individuals with recurrent MDD.
METHODS: Data on lifetime trauma exposures and clinical symptoms were collected using the Diagnostic Interview for Genetic Studies version 3.0 and best estimate diagnoses of MDD, PTSD, and other DSM-IV Axis I disorders were reported with best estimated age of onset.
RESULTS: The lifetime prevalence of suicide attempt in this sample was 28%. Lifetime PTSD was diagnosed in 205 (14.3%) participants. We used discrete time-survival analyses to take into account timing in the PTSD-suicide attempt relationship while adjusting for demographic variables (gender, race, age, and education level) and comorbid diagnoses prior to trauma exposure. PTSD was an independent predictor of subsequent suicide attempt (HR = 2.5, 95% CI: 1.6, 3.8; P < .0001). Neither assaultive nor nonassaultive trauma without PTSD significantly predicted subsequent suicide attempt after Bonferroni correction. The association between PTSD and subsequent suicide attempt was driven by traumatic events involving assaultive violence (HR = 1.7, 95% CI: 1.3, 2.2; P< .0001).
CONCLUSIONS: Among those with recurrent MDD, PTSD appears to be a vulnerability marker of maladaptive responses to traumatic events and an independent risk factor for attempted suicide. Additional studies examining differences between those with and without PTSD on biological measures might shed light on this potential vulnerability.
Authors:
Daniel Stevens; Holly C Wilcox; Dean F MacKinnon; Francis M Mondimore; Barbara Schweizer; Dunya Jancic; William H Coryell; Myrna M Weissman; Douglas F Levinson; James B Potash
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-07-24
Journal Detail:
Title:  Depression and anxiety     Volume:  30     ISSN:  1520-6394     ISO Abbreviation:  Depress Anxiety     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-10     Completed Date:  2014-05-30     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  9708816     Medline TA:  Depress Anxiety     Country:  United States    
Other Details:
Languages:  eng     Pagination:  940-6     Citation Subset:  IM    
Copyright Information:
© 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Comorbidity
Depressive Disorder, Major / complications*,  psychology
Female
Humans
Life Change Events*
Logistic Models
Male
Middle Aged
Prevalence
Recurrence
Risk Factors
Stress Disorders, Post-Traumatic / complications*,  diagnosis,  psychology
Suicide, Attempted / psychology*,  statistics & numerical data
Violence / psychology*
Grant Support
ID/Acronym/Agency:
K24 MH064197/MH/NIMH NIH HHS; K24MH64197/MH/NIMH NIH HHS; R01 MH059542/MH/NIMH NIH HHS; R01 MH059552/MH/NIMH NIH HHS; R01 MH060912/MH/NIMH NIH HHS; R01 MH061686/MH/NIMH NIH HHS; R01MH059542/MH/NIMH NIH HHS; R01MH059552/MH/NIMH NIH HHS; R01MH060912/MH/NIMH NIH HHS; R01MH061686/MH/NIMH NIH HHS; T32 GM007309/GM/NIGMS NIH HHS
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