Document Detail


Posttraumatic Epilepsy: What's Contusion Got to Do With It?
MedLine Citation:
PMID:  22690135     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Text of Abstract Liability to develop posttraumatic epilepsy (PTE) correlates in a general way with trauma dose. While contusion of the brain produces an admixture of extravasated blood, edema fluid and necrotic tissue at the site of skull trauma and in regions remote from the direct force, an unpredictable cascade of shearing injury, torsion and rotation and a myriad of physiological changes occur in structures subject to the mechanical pressure wave. Animal models mimic components of injury, some more thoroughly than others. Designing a treatment that is a prophylaxis for the development of PTE awaits understanding the mechanisms of epileptogenesis initiated by trauma.
Authors:
L James Willmore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsy currents / American Epilepsy Society     Volume:  12     ISSN:  1535-7511     ISO Abbreviation:  Epilepsy Curr     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-23     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  101135954     Medline TA:  Epilepsy Curr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  -    
Affiliation:
Department of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO.
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