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Posttransplant sCD30 as a Predictor of Kidney Graft Outcome.
MedLine Citation:
PMID:  21505378     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND.: Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available. METHODS.: In a prospective multicenter study, we investigated whether posttransplant measurement of the T-cell activation marker soluble CD30 (sCD30) can be used for estimating the risk of graft loss in kidney transplant recipients. Pre- and posttransplant sera of 2322 adult deceased-donor kidney recipients were tested for serum sCD30 content using a commercial enzyme-linked immunosorbent assay. RESULTS.: sCD30 decreased posttransplant and reached a nadir on day 30. Patients with a high sCD30 of more than or equal to 40 U/mL on day 30 showed a subsequent graft survival rate after 3 years of 78.3±4.1%, significantly lower than the 90.3±1.0% rate in recipients with a low sCD30 on day 30 of less than 40 U/mL (log-rank P<0.001; Cox hazard ratio 2.02, P<0.001). Although an association was found between pre- and posttransplant sCD30 levels, patients with high sCD30 on posttransplant day 30 demonstrated significantly lower 3-year graft survival irrespective of the pretransplant level. CONCLUSIONS.: Our data suggest that posttransplant measurement of sCD30 on day 30 is a predictor of subsequent graft loss in kidney transplant recipients and that sCD30 may potentially serve as an indicator for adjustment of immunosuppressive medication.
Authors:
Caner Süsal; Bernd Döhler; Mahmoud Sadeghi; Kaija T Salmela; Rolf Weimer; Martin Zeier; Gerhard Opelz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Transplantation     Volume:  -     ISSN:  1534-6080     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany. 2 Division of Transplantation, 4th Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland. 3 Department of Internal Medicine, University Clinic of Giessen and Marburg, Campus Giessen, Giessen, Germany. 4 Department of Nephrology, University of Heidelberg, Heidelberg, Germany.
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