| Posttransplant diabetes mellitus in renal allograft recipients: A prospective multicenter study at 2 years. | |
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MedLine Citation:
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PMID: 17175323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the incidence and risk factors for the development of diabetes mellitus after kidney transplantation (PTDM). A total of 1783 nondiabetic renal allograft recipients transplanted from January 2000 to December 2002 were included. Diabetes was diagnosed following American Diabetes Association criteria. While 1276 patients were treated with tacrolimus (Tac), mycophenolate mofetil (MMF), and steroids, 507 patients received cyclosporine-ME (CsA), MMF, and steroids. PTDM incidence at 6, 12, and 24 months was 14.2%, 12.8%, and 13.3%, respectively. Cumulative incidence during the follow-up was 21.6%. Only 121 of the diabetic patients (47.6%) at 6 months remained diabetic at 24 months. Furthermore, 60 patients of 116 patients on insulin at 6 months (51.7%) remained on treatment at 24 months. The cumulative incidence of PTDM was similar in the two immunosuppressive treatments (19.7% on CsA-MMF vs 22.3% on Tac-MMF; P = NS). However, at 24 months, 14 of 50 diabetic patients on CsA-MMF (28%) and 74 of 161 patients on Tac-MMF (45.9%) were on insulin treatment (P < .05). By Cox regression analysis, age older than 60 years (RR 1.61; 95%CI 1.28-2.04; P < .001), body mass index (BMI) > 30 kg/m2 at transplantation (RR 1.66; 95%CI 1.27-2.16; P < .001), and immunosuppression with Tac (RR 1.30; 95%CI 1.02-1-66; P = .033) were associated with PTDM. In conclusions, the incidence of PTDM at 24 months in immunosuppressive protocols including MMF is about 22%, and it is associated with older age, increased BMI, and immnunosuppression with Tac. |
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Authors:
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R Marcén; J M Morales; D del Castillo; J M Campistol; D Serón; F Valdés; F Anaya; A Andrés; M Arias; J Bustamante; L Capdevila; F Escuin; S Gil-Vernet; M Gonzalez-Molina; I Lampreave; F Oppenheimer; L Pallardó; |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-18 Completed Date: 2007-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 3530-2 Citation Subset: IM |
Affiliation:
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Servicio de Nefrología, Hospital Ramón y Cajal, Madrid, Spain. rmarcen.hrc@salud.madrid.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Adult Body Mass Index Diabetes Mellitus / epidemiology* Drug Therapy, Combination Female Follow-Up Studies Humans Immunosuppressive Agents / therapeutic use Incidence Kidney Transplantation / adverse effects* Male Middle Aged Postoperative Complications / epidemiology Prospective Studies Time Factors Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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