Document Detail


Posttranslational modification of therapeutic proteins in plants.
MedLine Citation:
PMID:  15003218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plants have emerged as an alternative to current systems for the production of therapeutic proteins. The advantages of plants for the low-cost and large-scale production of safe and biologically active mammalian proteins have been documented recently. A major advantage of transgenic plants over production systems that are based on yeast or Escherichia coli is their ability to perform most of the posttranslational modifications (PTMs) that are required for the bioactivity and pharmacokinetics of recombinant therapeutic proteins. Furthermore, recent advances in the control of PTMs in transgenic plants have made it possible for plants to perform, at least to some extent, human-like modifications of recombinant proteins. Hence, plants have become a suitable alternative to animal cell factories for the production of therapeutic proteins.
Authors:
Véronique Gomord; Loïc Faye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in plant biology     Volume:  7     ISSN:  1369-5266     ISO Abbreviation:  Curr. Opin. Plant Biol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-08     Completed Date:  2004-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883395     Medline TA:  Curr Opin Plant Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-81     Citation Subset:  IM    
Affiliation:
CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France. vgomord@crihan.fr
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MeSH Terms
Descriptor/Qualifier:
Biological Factors / biosynthesis*,  chemistry
Fatty Acids / chemistry,  metabolism
Genetic Engineering / methods
Glycosylation
Ions / chemistry,  metabolism
Oxidation-Reduction
Plant Proteins / genetics*,  metabolism
Plants / genetics*,  metabolism
Protein Processing, Post-Translational / genetics*
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Fatty Acids; 0/Ions; 0/Plant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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