Document Detail


Posttraining but not pretraining lesions of the hippocampus interfere with feature-negative discrimination of fear-potentiated startle.
MedLine Citation:
PMID:  12542229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have suggested that the hippocampus may play an important role in some forms of inhibitory learning. The goal of the present study was to assess whether the hippocampus is also important for inhibition of fear acquired after serial feature-negative discrimination training. Rats were given aspiration lesions of the hippocampus either before or after training in which a target light was paired with shock when presented alone, but not paired with shock when presented in serial compound with a noise feature (light+/noise-->light-). Conditioned fear to the target stimulus and feature-target compound were measured with fear-potentiated startle. Pre-training lesion of the hippocampus did not disrupt feature-negative discrimination performance relative to sham-operated and cortical lesioned controls. In contrast, hippocampal lesions performed after training severely disrupted performance. Specifically, rats with hippocampal lesions failed to inhibit fear when the noise feature was presented in compound with the target. However, these rats could reacquire the feature-negative discrimination. These observations suggest that the hippocampus may normally be involved in retention or retrieval of serial feature-negative discrimination; however, in its absence feature-negative discrimination can still be acquired.
Authors:
Scott A Heldt; Gary D Coover; William A Falls
Related Documents :
16811809 - Peak shift as a function of multiple schedules of reinforcement.
12542229 - Posttraining but not pretraining lesions of the hippocampus interfere with feature-nega...
2589109 - Stimulus modality effects on transformations of conditioned enhancement and conditioned...
16812269 - Positive and negative contrast as a function of component duration for key pecking and ...
2498929 - Two types of bias in psychophysical detection and recognition procedures: nonparametric...
16812019 - Parameters affecting the maintenance of negatively reinforced key pecking.
16658109 - The development of photosynthesis in a greening mutant of chlorella and an analysis of ...
22438499 - Perceived pattern regularity computed as a summary statistic: implications for camouflage.
22255639 - Motion-robust mri through real-time motion tracking and retrospective super-resolution ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hippocampus     Volume:  12     ISSN:  1050-9631     ISO Abbreviation:  Hippocampus     Publication Date:  2002  
Date Detail:
Created Date:  2003-01-24     Completed Date:  2003-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-86     Citation Subset:  IM    
Affiliation:
Department of Psychology, Northern Illinois University, DeKalb, Illinois 60115, USA. sheldt@niu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Avoidance Learning / physiology*
Conditioning (Psychology) / physiology
Discrimination Learning / physiology*
Fear / physiology*
Hippocampus / injuries,  physiopathology*,  surgery
Learning Disorders / pathology,  physiopathology*
Male
Memory Disorders / pathology,  physiopathology*
Neocortex / injuries,  physiopathology,  surgery
Neural Pathways / injuries,  physiopathology,  surgery
Photic Stimulation
Rats
Rats, Sprague-Dawley
Startle Reaction / physiology*
Grant Support
ID/Acronym/Agency:
MH59681/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Trans-synaptic increase of hypoxic tolerance in hippocampus upon physical challenge with two-photon ...
Next Document:  Alterations in the balance of protein kinase and phosphatase activities and age-related impairments ...