| Postthymectomy wasting associated with autoimmune phenomena. I. Antiglobulin-positive anemia in A and C57BL-6 Ks mice. | |
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MedLine Citation:
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PMID: 4164823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Mice of A and C(57)BL/6 Ks strains, thymectomized at birth acquire wasting disease in 84.1% (A) and 77.1% (C(57)BL/6 Ks) of the cases. There is no sex predelection. 2. Anemia in these animals is characterized by shortened red cell survival and increased fragility to hypotonic salt solutions. Among thymectomized A mice reticulocytosis is absent and extramedullary hematopoiesis is found in the spleen in the presence of bone marrow hypoplasia for the erythroid and lymphocyte series. 3. Positive antiglobulin tests of the red cells were observed in all the thymectomized C(57)BL/6 Ks (7/7) and 71.2% of the A strains (62/87). Normal mice do not show positive Coombs' tests. 4. The globulin coat on the A strain consists of IgM, whereas beta(1C) and IgG are not detectable. By contrast, red cell coats of NZB mice developing spontaneous autoimmune hemolytic anemia show IgM and beta(1C), but these erythrocytes do not react with anti-gamma chain antibodies. Another difference in the globulin coats of the two types of erythrocytes is that the IgM on NZB red cells has available light chain determinants but these are apparently hidden or absent in the case of sensitized erythrocytes. The difference in antibody coating, association with a component of complement in one but not the other, suggests a different mechanism for the immune surface phenomenon in each instance. 5. Anemia in NZB mice is associated with reticulocytosis while that in thymectomized A mice is not. 6. Thymectomy appears to initiate a chain of events leading to a series of autoimmune phenomena which may be due to alteration in host response consequent to loss of thymic tissue and thymic dependent functions or alternatively to infection to which increased susceptibility exists as a result of thymic extirpation. |
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Authors:
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E J Yunis; R Hong; M A Grewe; C Martinez; E Cornelius; R A Good |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 125 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1967 May |
Date Detail:
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Created Date: 1967-07-10 Completed Date: 1967-07-10 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 947-66 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hemolytic
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blood Animals Animals, Newborn Antibodies, Anti-Idiotypic* Autoimmune Diseases / blood, etiology* Bone Marrow / analysis Bone Marrow Cells Coombs' Test Erythrocytes / analysis Graft vs Host Disease / etiology* Hematocrit Megakaryocytes / analysis Mice Osmotic Fragility Reticulocytes / analysis Spleen / cytology Thymectomy / adverse effects* gamma-Globulins |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/gamma-Globulins |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1967 by The Rockefeller University Press Received Day: 24 Month: 1 Year: 1967 Print publication date: Day: 1 Month: 5 Year: 1967 Volume: 125 Issue: 5 First Page: 947 Last Page: 966 ID: 2138208 PubMed Id: 4164823 |
| POSTTHYMECTOMY WASTING ASSOCIATED WITH AUTOIMMUNE PHENOMENA : I. ANTIGLOBULIN-POSITIVE ANEMIA IN A AND C57BL/6 KS MICE | |
| Edmond J. Yunis | |
| Richard Hong | |
| Mary Alice Grewe | |
| Carlos Martinez | |
| Eugene Cornelius | |
| Robert A. Good | |
| From the Departments of Physiology and Laboratory Medicine, and the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis |
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