Document Detail


Postsynaptic adrenergic unresponsiveness in hypotensive haemodialysis patients.
MedLine Citation:
PMID:  7329986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to ascertain the significance of autonomic dysfunction in hypotensive maintenance haemodialysis patients, plasma norepinephrine (NE) was measured by radioenzymatic assay in 15 nondiabetic uraemic subjects of similar age and time on dialysis, five of them chronically hypotensive and 10 normotensive. Hypotensive patients had: 1) Significantly higher NE levels than their normotensive counterparts, both in basal conditions and after orthostatism and 2) significantly lesser increments in mean arterial blood pressure during a NE infusion than the normotensive group. Rather than implicating a mechanism based on autonomic neuropathy, our results suggest that in haemodialysis patients with chronic hypotension, there is a defect located at the adrenergic postsynaptic level.
Authors:
A Botey; J Gaya; J Montoliu; A Torras; F Rivera; J López-Pedret; L Revert
Related Documents :
12420086 - Eye examination-induced syncope role of trigeminal afferents.
16106496 - The effects of forearm rotation on three wrist measurements: radial inclination, radial...
616046 - The mechanism of orthostatic and haemorrhage fainting.
3173816 - Orthostatic hypotension occurring after discontinuation of long-term minoxidil therapy.
18028576 - Myocardial performance index during rapidly changing loading conditions: impact of diff...
9049526 - Assessing the clinical need for short-term conversion from oral to parenteral angiotens...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  18     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  586-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autonomic Nervous System Diseases / etiology*
Blood Pressure / drug effects
Humans
Hypotension / blood*,  etiology
Kidney Failure, Chronic / physiopathology,  therapy
Male
Middle Aged
Norepinephrine / blood*,  pharmacology
Posture
Renal Dialysis / adverse effects*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The influence of 1 alpha-hydroxycholecalciferol on left ventricular function in end-stage renal fail...
Next Document:  Peripheral haematocrit modulates erythropoietin production and kinetics of reticulocytes in chronic ...