Document Detail

Postsynaptic adrenergic unresponsiveness in hypotensive haemodialysis patients.
MedLine Citation:
PMID:  7329986     Owner:  NLM     Status:  MEDLINE    
In order to ascertain the significance of autonomic dysfunction in hypotensive maintenance haemodialysis patients, plasma norepinephrine (NE) was measured by radioenzymatic assay in 15 nondiabetic uraemic subjects of similar age and time on dialysis, five of them chronically hypotensive and 10 normotensive. Hypotensive patients had: 1) Significantly higher NE levels than their normotensive counterparts, both in basal conditions and after orthostatism and 2) significantly lesser increments in mean arterial blood pressure during a NE infusion than the normotensive group. Rather than implicating a mechanism based on autonomic neuropathy, our results suggest that in haemodialysis patients with chronic hypotension, there is a defect located at the adrenergic postsynaptic level.
A Botey; J Gaya; J Montoliu; A Torras; F Rivera; J López-Pedret; L Revert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  18     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  586-91     Citation Subset:  IM    
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MeSH Terms
Autonomic Nervous System Diseases / etiology*
Blood Pressure / drug effects
Hypotension / blood*,  etiology
Kidney Failure, Chronic / physiopathology,  therapy
Middle Aged
Norepinephrine / blood*,  pharmacology
Renal Dialysis / adverse effects*
Reg. No./Substance:

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