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Postsurgical thyroid remnant estimation by (99m) Tc-pertechnetate scintigraphy predicts radioiodine ablation effectiveness in patients with differentiated thyroid carcinoma.
MedLine Citation:
PMID:  20824809     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND.: The purpose of this study was to evaluate the relationship between postsurgical neck (99m) technetium ((99m) Tc)-pertechnetate uptake and the rate of successful remnant ablation after radioiodine treatment in patients with differentiated thyroid carcinoma (DTC). METHODS.: Retrospectively enrolled were 232 patients with DTC who underwent total thyroidectomy and fixed activity ablation with 3.7 GBq (131) I. The (99m) Tc scans were performed on all patients before (131) I administration. Thyroid ablation was assessed after 6 to 12 months by thyroid-stimulating hormone (TSH)-stimulated (131) I-WBS and thyroglobulin measurement. The rate of successful ablation, occurrence of radioiodine-induced thyroiditis, and length of hospitalization were correlated with the (99m) Tc-pertechnetate scintigraphy results. RESULTS.: A (99m) Tc uptake was significantly lower in ablated versus nonablated patients (p < .001). High (99m) Tc-pertechnetate uptake, especially greater than 1.4%, predicted a high-risk of unsuccessful ablation. Higher (99m) Tc-pertechnetate uptake was also related to prolonged hospitalization and the occurrence of radioiodine-induced thyroiditis. CONCLUSION.: The (99m) Tc-pertechnetate scintigraphy is a simple and feasible tool to evaluate thyroid remnants and to predict radioiodine ablation results in patients with DTC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011.
Authors:
Luca Giovanella; Sergio Suriano; Riccardo Ricci; Luca Ceriani; Frederik Anton Verburg
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Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Head & neck     Volume:  33     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  552-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Nuclear Medicine, PET-CT Center and Thyroid Unit, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland. luca.giovanella@eoc.ch.
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