Document Detail


Postsurgical stage I bronchogenic carcinoma: morbid implications of recurrent disease.
MedLine Citation:
PMID:  6091575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three hundred forty-six patients with post-surgical non-small cell Stage I bronchogenic carcinoma were followed from 5.0 to 10.8 years (median, 7.0 years). Recurrent cancer developed in 135 patients (39%). Seventy-five recurrences were nonregional metastases (55.6%); 35 (25.9%), a subsequent primary lung cancer; and 25 (18.5%), local recurrence only. The rate of recurrent lung cancer decreased from 15.0 patients per 100 patient-years the first postoperative year to 2.3 the seventh and subsequent years. The rate of recurrence varied among the three different types of recurrent cancer. Five years after pulmonary resection, 70.0% of patients with T1 N0 neoplasms had no evidence of recurrence compared with 58.2% of patients with T2 N0 tumors (p = 0.012) and only 31.8% of patients with T1 N1 neoplasms (p less than 0.001). There was no significant difference in overall rate of recurrence among the various cell types. Currently, 174 patients are alive. Lung cancer survival (Kaplan-Meier) was 69.1% at 5 years and 61.9% at 9 years. At 2 years following detection of subsequent lung cancer, 51.8% of patients with subsequent primary lung cancer had survived lung cancer compared with 23.4% for those with local recurrence and only 8.9% for those with nonregional metastases.
Authors:
P C Pairolero; D E Williams; E J Bergstralh; J M Piehler; P E Bernatz; W S Payne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  38     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-16     Completed Date:  1984-11-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / mortality,  pathology,  surgery
Adenocarcinoma, Bronchiolo-Alveolar / mortality,  pathology,  surgery
Aged
Carcinoma, Bronchogenic / mortality,  pathology,  surgery*
Carcinoma, Small Cell / mortality,  pathology,  surgery
Carcinoma, Squamous Cell / mortality,  pathology,  surgery
Female
Follow-Up Studies
Humans
Lung Neoplasms / mortality,  pathology,  surgery*
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local / mortality*
Pneumonectomy
Prognosis
Grant Support
ID/Acronym/Agency:
N0 1-CN-53886/CN/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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