Document Detail

Postsurgery enteral nutrition in head and neck cancer patients.
MedLine Citation:
PMID:  12428179     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using an arginine-enriched diet, could improve nutritional variables as well as clinical outcomes. DESIGN: Randomized clinical trial. SETTING: Tertiary care. SUBJECTS: A population of 47 patients with oral and laryngeal cancer were enrolled. INTERVENTIONS: At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplemented with arginine and fiber (group I); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II). RESULTS: No significant intergroup differences in the trend of the three plasma proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (17.4% group I and 8.3% group II; NS). During the 3 months after hospital discharge five patients died; no differences were detected between groups (13% group I and 8.3% group II; NS). The incidences postoperative infection complications were similar (nine patients) in both groups (21.7% group I and 16.7% group II; NS). Fistula were less frequent in enriched nutrition group (0% group I and 20.8% group II; P<0.05); wound infection was more frequent in group II, but without statistical difference (4.3% group I and 12.5% group II; NS). The length of postoperative stay was 22.8+/-11.8 days in the enriched group and 31.2+/-19.1 days in the control group (P=0.07). CONCLUSIONS: In conclusion, enriched formula improves local wound complications in postoperative head and neck cancer patients. Our results suggest that these patients could benefit from an immunonutrient-enhanced enteral formula.
D A de Luis; R Aller; O Izaola; L Cuellar; M C Terroba
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  56     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-12     Completed Date:  2003-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1126-9     Citation Subset:  IM    
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Spain.
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MeSH Terms
Arginine / administration & dosage*,  therapeutic use
Dietary Fiber / administration & dosage*,  therapeutic use
Enteral Nutrition*
Head and Neck Neoplasms / complications,  immunology,  surgery*,  therapy*
Length of Stay
Middle Aged
Nutrition Disorders / immunology,  prevention & control
Nutritional Status
Postoperative Care
Postoperative Complications / epidemiology,  prevention & control*
Prospective Studies
Surgical Wound Infection / epidemiology
Treatment Outcome
Reg. No./Substance:

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