| Postprandial triglyceride responses to aerobic exercise and extended-release niacin. | |
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MedLine Citation:
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PMID: 18614721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aerobic exercise and niacin are frequently used strategies for reducing serum triglycerides, and, yet, there is no information regarding the combined effects of these strategies on postprandial triglycerides. OBJECTIVE: We compared the effects of aerobic exercise and 6 wk of extended-release niacin on postprandial triglycerides in men with the metabolic syndrome. DESIGN: Fifteen participants underwent each of 4 conditions: control--high-fat meal only (100 g fat); exercise--aerobic exercise performed 1 h before a high-fat meal; niacin--high-fat meal consumed after 6 wk of niacin; and niacin + exercise--high-fat meal consumed after 6 wk of niacin and 1 h after aerobic exercise. Temporal responses for triglyceride and insulin concentrations were measured and total (AUC(T)) and incremental (AUC(I)) areas under the curve were calculated. Differences were determined by using a 2-factor repeated-measures analysis of variance (P < 0.05 for all). RESULTS: Exercise lowered the triglyceride AUC(I) by 32% compared with control (724 +/- 118 and 1058 +/- 137, respectively). Niacin had no influence on the triglyceride AUC(I) and attenuated the triglyceride-lowering effect of exercise when combined. Niacin + exercise had no effect on the triglyceride AUC(I) but decreased the insulin AUC(I) after niacin administration. CONCLUSIONS: Aerobic exercise lowers the postprandial triglyceride response to a high-fat meal. Niacin lowers fasting but not postprandial triglycerides and appears to influence the triglyceride-lowering effect of aerobic exercise when combined. However, exercise decreases postprandial insulin concentrations after niacin administration, which illustrates the potential metabolic benefits of exercise in persons taking niacin. |
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Authors:
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Eric P Plaisance; Michael L Mestek; A Jack Mahurin; J Kyle Taylor; Jose Moncada-Jimenez; Peter W Grandjean |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-10 Completed Date: 2008-07-31 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 30-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Kinesiology, Auburn University, Auburn, AL, USA. plaisep@auburn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Antilipemic Agents / therapeutic use* Area Under Curve Combined Modality Therapy Cross-Over Studies Dietary Fats / administration & dosage*, metabolism Exercise / physiology* Factor Analysis, Statistical Humans Hypertriglyceridemia / therapy* Insulin / blood Male Metabolic Syndrome X Middle Aged Niacin / therapeutic use* Postprandial Period Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Dietary Fats; 0/Triglycerides; 11061-68-0/Insulin; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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