Document Detail


Postprandial total and HMW adiponectin following a high-fat meal in lean, obese and diabetic men.
MedLine Citation:
PMID:  23462948     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Objectives:Recent work suggests that macronutrients are pro-inflammatory and promote oxidative stress. Reports of postprandial regulation of total adiponectin have been mixed, and there is limited information regarding postprandial changes in high molecular weight (HMW) adiponectin. The aim of this study was to assess the effect of a standardised high-fat meal on metabolic variables, adiponectin (total and HMW), and markers of inflammation and oxidative stress in: (i) lean, (ii) obese non-diabetic and (iii) men with type 2 diabetes mellitus (T2DM).Subjects/Methods:Male subjects: lean (n=10), obese (n=10) and T2DM (n=10) were studied for 6 h following both a high-fat meal and water control. Metabolic variables (glucose, insulin, triglycerides), inflammatory markers (interleukin-6 (IL6), tumour necrosis factor (TNF)α, high-sensitivity C-reactive protein (hsCRP), nuclear factor (NF)κB expression in peripheral blood mononuclear cells (p65)), indicators of oxidative stress (oxidised low density lipoprotein (oxLDL), protein carbonyl) and adiponectin (total and HMW) were measured.Results:No significant changes in TNFα, p65, oxLDL or protein carbonyl concentrations were observed. Overall, postprandial IL6 decreased in subjects with T2DM but increased in lean subjects, whereas hsCRP decreased in the lean cohort and increased in obese subjects. There was no overall postprandial change in total or HMW adiponectin in any group. Total adiponectin concentrations changed over time following the water control, and the response was significantly different in lean subjects compared with subjects with T2DM (P=0.04).Conclusions:No consistent significant postprandial inflammation, oxidative stress or regulation of adiponectin was observed in this study. Findings from the water control suggest differential basal regulation of total adiponectin in T2DM compared with lean controls.European Journal of Clinical Nutrition advance online publication, 6 March 2013; doi:10.1038/ejcn.2013.49.
Authors:
L K Phillips; J M Peake; X Zhang; I J Hickman; D R Briskey; B E Huang; P Simpson; S-H Li; J P Whitehead; J H Martin; J B Prins
Related Documents :
23873128 - Effects on glucagon-like peptide-1 secretion by distal ileal administration of nutrients.
23033248 - Prospective associations of b-type natriuretic peptide with markers of left ventricular...
21134878 - Comparison of pharmacokinetic properties, physicochemical stability, and pump compatibi...
21880708 - Non-equivalent role of inter- and intramolecular hydrogen bonds in the insulin dimer in...
20864818 - Autophagy: roles in obesity-induced er stress and adiponectin downregulation in adipocy...
8291588 - Decreasing stromal iris pigmentation as a risk factor for age-related macular degenerat...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-06
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nutritional care in children with cystic fibrosis: are our patients becoming better?
Next Document:  Determinants of adherence to gluten-free diet in Greek children with coeliac disease: a cross-sectio...