| Postprandial splanchnic haemodynamic changes in patients with liver cirrhosis and patent paraumbilical vein. | |
| | |
MedLine Citation:
|
PMID: 15618843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The haemodynamic changes induced by a meal on collateral vessels in portal hypertensive cirrhotic patients are not well characterized. We aimed to study the postprandial modifications of splanchnic circulation in patients with a patent paraumbilical vein (PUV). METHODS: We studied 10 cirrhotic patients with patent PUV and 10 matched cirrhotic patients without PUV, by using echo colour Doppler at baseline and 15, 30 and 45 min after a standard mixed liquid meal (400 ml; 600 kcal). Calibre and blood flow velocities of the superior mesenteric artery, portal vein and PUV were obtained; congestion index of portal vein, portal blood flow, paraumbilical blood flow and effective portal liver perfusion were calculated; intrahepatic and intrasplenic arterial resistance and pulsatility indexes were recorded. RESULTS: We observed a postprandial splanchnic hyperaemia (superior mesenteric artery and portal vein blood flow increased after the meal in both groups; ANOVA P < 0.05), with no changes of hepatic impedance. In PUV patients, PUV constricted significantly postprandially, maximally at 30 min (calibre -17.5 +/- 7.0%; P = 0.003). Intrasplenic impedance, which may reflect portal pressure, increased, maximally at 30 min (pulsatility index +22.6 +/- 27.0%; P = 0.01), and inversely correlated with PUV vasoconstriction (R = 0.75, P = 0.01). In non-PUV patients intrasplenic impedance did not change. Portal liver perfusion increased similarly in both groups. CONCLUSIONS: PUV constricts after the meal, and this vasoconstriction is associated with an increase of splenic impedance which may indicate the postprandial increase of portal pressure observed in cirrhosis. The increase in postprandial portal liver perfusion in the PUV group is allowed by a paradox constriction of the collateral vessel. |
| | |
Authors:
|
Annalisa Berzigotti; Susanna Dapporto; Lucia Angeloni; Stefano Ramilli; Giampaolo Bianchi; Maria Cristina Morelli; Donatella Magalotti; Marco Zoli |
Related Documents
:
|
8513773 - The effect of tyre pressure on the economy of cycling. 7750353 - High-output congestive heart failure following transjugular intrahepatic portal-systemi... 10983673 - Fetal growth and blood pressure in a danish population aged 31-51 years. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of gastroenterology & hepatology Volume: 16 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-12-24 Completed Date: 2005-03-17 Revised Date: 2009-10-16 |
Medline Journal Info:
|
Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
|
Languages: eng Pagination: 1339-45 Citation Subset: IM |
Affiliation:
|
Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Università di Bologna, Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use Analysis of Variance Blood Flow Velocity / physiology Collateral Circulation / physiology Female Hemodynamics / physiology Humans Hyperemia / complications, physiopathology Hypertension, Portal / physiopathology Liver Cirrhosis / complications, drug therapy, physiopathology* Male Mesenteric Artery, Superior / physiopathology Middle Aged Portal Pressure / physiology Portal System / physiopathology Portal Vein / physiopathology Postprandial Period / physiology* Pulsatile Flow / physiology Splanchnic Circulation / physiology* Umbilical Veins / physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nitric-oxide-lowering effect of terlipressin in decompensated cirrhosis: comparison to the molecular...
Next Document: Liver disease is a major cause of mortality following allogeneic bone-marrow transplantation.