Document Detail

Postprandial metabolism and aversive response in rats fed a threonine-devoid diet.
MedLine Citation:
PMID:  10896888     Owner:  NLM     Status:  MEDLINE    
Lack of an indispensable amino acid in the diet induces a rapid reduction in food intake. In this study, we assessed whether the anorectic signal after ingestion of a meal lacking threonine originated from either direct perception of the decrease in plasma threonine or from an indirect effect related to increased postprandial amino acid catabolism and energy expenditure. We observed that 3 g of such a meal was sufficient to induce an aversive response to the diet within 2 h. Postprandial changes to plasma ammonia and urea, urinary urea, and energy metabolism did not differ from those measured after a control meal. In contrast, plasma threonine levels fell within 1 h after the meal. It is concluded that an increase in postprandial energy expenditure is not involved in the anorectic response to eating a threonine-devoid diet. The drop in plasma threonine levels may be a potential signal, but the fact that the decrease in food intake occurred 1 h after the decrease in plasma threonine questions a direct causal relationship.
P C Even; V Rolland; S Feurté; G Fromentin; S Roseau; S Nicolaïdis; D Tomé
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  279     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-27     Completed Date:  2000-09-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R248-54     Citation Subset:  IM    
Institut National de la Recherche Agronomique de Paris Arignon, Laboratoire de Nutrition Humaine etPhysiologie Intestinale, 75231 Paris Cedex 05, France.
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MeSH Terms
Amino Acids / metabolism
Ammonia / blood
Anorexia / etiology,  metabolism
Eating / physiology
Energy Intake / physiology
Energy Metabolism / physiology
Food Preferences / physiology*
Food, Formulated
Glucose / metabolism
Lipid Metabolism
Postprandial Period / physiology*
Proteins / metabolism
Rats, Wistar
Threonine / blood,  deficiency*
Urea / blood
Reg. No./Substance:
0/Amino Acids; 0/Proteins; 50-99-7/Glucose; 57-13-6/Urea; 72-19-5/Threonine; 7664-41-7/Ammonia

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