Document Detail

Postprandial lipoproteins in non-insulin-dependent diabetes mellitus.
MedLine Citation:
PMID:  9272617     Owner:  NLM     Status:  MEDLINE    
People with non-insulin-dependent diabetes mellitus (NIDDM) have a higher incidence of cardiovascular disease (CVD) than the non-diabetic population. In addition, NIDDM patients have a spectrum of lipid abnormalities that may confer an increased risk of developing CVD. The pattern of dyslipidaemia seen in NIDDM patients is different from that seen in the non-diabetic population. This suggests that patients with NIDDM may need different lipid-lowering treatment from that used in the non-diabetic population. In the post-absorptive state, secretion of very low-density lipoprotein (VLDL) is higher in patients with NIDDM, possibly because of the impaired ability of insulin to inhibit lipolysis and to reduce hepatic VLDL secretion. Clearance of triglyceride-rich lipoproteins is also important in determining the extent of postprandial hyperlipidaemia. Lipoprotein lipase (LPL) reduces plasma lipoprotein concentration via several mechanisms. In patients with NIDDM, the capacity of LPL to minimize postprandial hyperlipidaemia may be reduced, although the pathophysiological basis of this is not known. Other changes in patients with NIDDM, such as modifications to cholesteryl ester transfer protein (CETP) and hepatic lipase activity, may also affect postprandial lipaemia but such effects are probably secondary to alterations in lipoprotein clearance. Present evidence suggests that postprandial hyperlipidaemia is atherogenic. There are, however, little specific data from patients with NIDDM. More studies are therefore needed to establish the optimal treatment of dyslipidaemia in patients with NIDDM.
S W Coppack
Related Documents :
3401287 - Further resolution and comparison of the heterogeneity of plasma low-density lipoprotei...
15047647 - Role of simvastatin as an immunomodulator in type 2 diabetes.
11932277 - Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacemen...
11597827 - Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance.
22766717 - Effect of soybean-lecithin as an enhancer of buccal mucosa absorption of insulin.
10675987 - First bioanalytical evaluation of nonpeptidic cage dimeric hiv-1 protease inhibitor n-b...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  14 Suppl 3     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-12-12     Completed Date:  1997-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S67-74     Citation Subset:  IM    
Department of Medicine, University College London Medical School, Whittington Hospital, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetes Mellitus, Type 2 / blood*,  complications,  metabolism
Hyperlipidemias / metabolism,  physiopathology*,  therapy
Lipoproteins / blood,  metabolism*
Postprandial Period / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanisms of postprandial hyperlipidaemia--remnants and coronary artery disease.
Next Document:  Mechanisms of hepatic chylomicron remnant clearance.