| Postprandial lipoprotein metabolism: VLDL vs chylomicrons. | |
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MedLine Citation:
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PMID: 21531214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over the last two decades that the major increase in the postprandial lipoproteins after food intake occurs in the very low density lipoprotein (VLDL) remnants (apoB-100 particles), not CM or CM remnants (apoB-48 particles). This finding was obtained using the following three analytical methods; isolation of remnant-like lipoprotein particles (RLP) with specific antibodies, separation and detection of lipoprotein subclasses by gel permeation HPLC and determination of apoB-48 in fractionated lipoproteins by a specific ELISA. The amount of the apoB-48 particles in the postprandial RLP is significantly less than the apoB-100 particles, and the particle sizes of apoB-48 and apoB-100 in RLP are very similar when analyzed by HPLC. Moreover, CM or CM remnants having a large amount of TG were not found in the postprandial RLP. Therefore, the major portion of the TG which is increased in the postprandial state is composed of VLDL remnants, which have been recognized as a significant risk for cardiovascular disease. |
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Authors:
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Katsuyuki Nakajima; Takamitsu Nakano; Yoshiharu Tokita; Takeaki Nagamine; Akihiro Inazu; Junji Kobayashi; Hiroshi Mabuchi; Kimber L Stanhope; Peter J Havel; Mitsuyo Okazaki; Masumi Ai; Akira Tanaka |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-04-19 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 412 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-27 Completed Date: 2011-09-30 Revised Date: 2012-01-24 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1306-18 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan. nakajimak05@ybb.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chylomicrons / blood, metabolism* Humans Lipoproteins, VLDL / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL075675-05/HL/NHLBI NIH HHS; R01 HL091333-05/HL/NHLBI NIH HHS; UL1 RR024146-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Lipoproteins, VLDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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