| Postprandial lipaemia does not affect resting haemodynamic responses but does influence cardiovascular reactivity to dynamic exercise. | |
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MedLine Citation:
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PMID: 20420759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postprandial lipaemia impairs endothelial function, possibly by changes in oxidative stress, but whether this affects cardiac output and/or systemic vascular resistance (SVR) at rest and in response to dynamic exercise remains uncertain. The present study set out to investigate the effects of a high-fat meal (HFM) v. a low-fat, high-carbohydrate meal (HCM) on cardiac output and SVR. A HFM (50 g fat) and an isoenergetic HCM (5 g fat) were randomly fed to thirty healthy adults using a crossover design. Cardiac output, heart rate and blood pressure (BP) were measured, and stroke volume and SVR were calculated over a 3 h rest following the meal, during exercise 3 h postprandially and for 45 min post-exercise. Blood samples were collected at fasting, 3 h postprandially and immediately post-exercise. Plasma TAG increased by 63.8 % 3 h following the HFM, and NEFA fell by 94.1% 3 h after the HCM. There was a 9.8% rise in plasma 8-isoprostane-F2alpha concentration following the HFM, and a 6.2% fall following the HCM. Cardiac output increased postprandially, but the difference between meals at rest or exercise was not statistically significant. The HFM resulted in a 3.2 mmHg (95% CI 0.7, 5.7) smaller increase in exercise mean arterial BP compared with the HCM due to a greater fall in exercise SVR. Postprandial lipaemia induced by a HFM does not affect cardiac output and/or SVR at rest, but it blunts the increase in BP during exercise. |
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Authors:
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Victoria G Rontoyanni; Philip J Chowienczyk; Thomas A B Sanders |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 863-71 Citation Subset: IM |
Affiliation:
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Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. victoria.rontoyanni@kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Cardiac Output Cross-Over Studies Diet, Carbohydrate-Restricted Diet, Fat-Restricted Dietary Carbohydrates / administration & dosage* Dietary Fats / administration & dosage* Dinoprost / analogs & derivatives, blood Exercise / physiology* Female Heart Rate Hemodynamics* Humans Hyperlipidemias / physiopathology* Male Postprandial Period / physiology Single-Blind Method Stroke Volume Triglycerides / blood Vascular Resistance Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Triglycerides; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost |
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