| Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models. | |
| | |
MedLine Citation:
|
PMID: 22144044 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients. Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) low-fat, high-complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids (PUFA) (LFHCC n-3), and (iv) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. We found that p65 gene expression is induced in adipose tissue (p=0.003) at the postprandial state. In addition, IκBα (p<0.001), MCP-1 (p<0.001) and IL-1β (p<0.001) gene expression was equally induced in the postprandial state, regardless of the quality and quantity of the dietary fat. Notably, IL-6 transcripts were only detected in the postprandial state. Conclusions: Our results indicate that individuals with MetS typically exhibit exacerbated adipose tissue postprandial inflammatory responses, which seem to be independent of the quality and quantity of dietary fat. |
| | |
Authors:
|
Maria E Meneses; Antonio Camargo; Pablo Perez-Martinez; Javier Delgado-Lista; Cristina Cruz-Teno; Yolanda Jimenez-Gomez; Juan A Paniagua; Francisco M Gutierrez-Mariscal; Francisco J Tinahones; Antonio Vidal-Puig; Helen M Roche; Francisco Perez-Jimenez; Maria M Malagon; Jose Lopez-Miranda |
Related Documents
:
|
18400664 - Behavior change and the freshman 15: tracking physical activity and dietary patterns in... 17497414 - Postnatal growth considerations for pbpk modeling. 7707674 - Sex differences in age development of a mouse inbred strain: body composition, adipocyt... 8074614 - A comparison of lumbosacral loads during static and dynamic activities. 7921374 - Comparison of three porcine restenosis models: the relative importance of hypercholeste... 15569844 - Postprandial hypertriglyceridemia increases circulating levels of endothelial cell micr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 55 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 1759-70 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital, University of Cordoba and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rice varieties in relation to rice bread quality.
Next Document: Vascular deconjugation of quercetin glucuronide: The flavonoid paradox revealed?