Document Detail

Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation.
MedLine Citation:
PMID:  12559548     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To analyze the effects of postprandial hypertriglyceridemia with or without antioxidant supplementation-on endothelial function as related to lipid oxidation in healthy young subjects. METHODS AND RESULTS: Ten healthy male subjects (mean age: 26 years) were examined three times in fasting state (10 hours) following a high-fat meal, a low-fat meal, or a high-fat meal with additional antioxidant vitamin E (800 IU), respectively. Serum triglycerides significantly increased 2 and 4 hours after eating the high-fat meal with or without additional vitamin E. Endothelium-dependent, flow-mediated brachial artery vasodilations (FMD; percentage change in diameter) changed from 13.3+/-1.1% to 6.6+/-1.1% (p<0.05), 7.1+/-0.6% (p<0.05), or 13.2+/-0.8% at 2, 4, or 6 hours after eating a high-fat meal. However, there were no changes of FMD observed following either a low-fat meal or a high-fat meal with additional vitamin E. The flow-dependent vasodilation inversely correlated to postprandial hypertriglyceridemia (r=-0.54, p<0.05). Serum malondialdehydes (MDA; lipid oxidation products) did not significantly change following ingestion of any of the 3 types of meal. CONCLUSIONS: This study suggests that postprandial hypertriglyceridemia-induced endothelial dysfunction is not associated with lipid oxidation and that the protective effects of vitamin E on endothelial function may be due to some alternative, as of yet unknown, mechanism.
Jang-Ho Bae; Michael Schwemmer; In-Kyu Lee; Hee-Ja Lee; Ki-Rack Park; Ki-Young Kim; Eberhard Bassenge
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  87     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-05-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea.
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MeSH Terms
Analysis of Variance
Antioxidants / administration & dosage*
Blood Flow Velocity
Brachial Artery / physiology
Cohort Studies
Cross-Over Studies
Dietary Fats / administration & dosage*
Endothelium, Vascular / physiology*
Hemodynamics / physiology
Hypertriglyceridemia / diagnosis*
Lipid Peroxidation / physiology*
Malondialdehyde / blood*
Postprandial Period
Reference Values
Vitamin E / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 0/Dietary Fats; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde

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