| Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. | |
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MedLine Citation:
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PMID: 12559548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To analyze the effects of postprandial hypertriglyceridemia with or without antioxidant supplementation-on endothelial function as related to lipid oxidation in healthy young subjects. METHODS AND RESULTS: Ten healthy male subjects (mean age: 26 years) were examined three times in fasting state (10 hours) following a high-fat meal, a low-fat meal, or a high-fat meal with additional antioxidant vitamin E (800 IU), respectively. Serum triglycerides significantly increased 2 and 4 hours after eating the high-fat meal with or without additional vitamin E. Endothelium-dependent, flow-mediated brachial artery vasodilations (FMD; percentage change in diameter) changed from 13.3+/-1.1% to 6.6+/-1.1% (p<0.05), 7.1+/-0.6% (p<0.05), or 13.2+/-0.8% at 2, 4, or 6 hours after eating a high-fat meal. However, there were no changes of FMD observed following either a low-fat meal or a high-fat meal with additional vitamin E. The flow-dependent vasodilation inversely correlated to postprandial hypertriglyceridemia (r=-0.54, p<0.05). Serum malondialdehydes (MDA; lipid oxidation products) did not significantly change following ingestion of any of the 3 types of meal. CONCLUSIONS: This study suggests that postprandial hypertriglyceridemia-induced endothelial dysfunction is not associated with lipid oxidation and that the protective effects of vitamin E on endothelial function may be due to some alternative, as of yet unknown, mechanism. |
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Authors:
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Jang-Ho Bae; Michael Schwemmer; In-Kyu Lee; Hee-Ja Lee; Ki-Rack Park; Ki-Young Kim; Eberhard Bassenge |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cardiology Volume: 87 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-31 Completed Date: 2003-05-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 259-67 Citation Subset: IM |
Affiliation:
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Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea. jhbae@kyuh.co.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Antioxidants / administration & dosage* Blood Flow Velocity Brachial Artery / physiology Cohort Studies Cross-Over Studies Dietary Fats / administration & dosage* Endothelium, Vascular / physiology* Hemodynamics / physiology Humans Hypertriglyceridemia / diagnosis* Lipid Peroxidation / physiology* Male Malondialdehyde / blood* Postprandial Period Probability Reference Values Vitamin E / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Dietary Fats; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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