| Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies. | |
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MedLine Citation:
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PMID: 23345190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, particularly obesity and insulin resistance. Accumulation of TRL in the postprandial state promotes the formation of small, dense low-density lipoproteins, as well as oxidative stress, inflammation, and endothelial dysfunction, all of which compound the risk of cardiovascular disease. The cardiovascular benefits of lifestyle modification (weight loss and exercise) and conventional lipid-lowering therapies (statins, fibrates, niacin, ezetimibe, and n-3 fatty acid supplementation) could involve their favorable effects on TRL metabolism. New agents, such as dual peroxisome-proliferator-activated receptor α/δ agonists, diacylglycerol, inhibitors of diacylglycerol acyltransferase 1 and microsomal triglyceride transfer protein, antisense oligonucleotides for apolipoprotein B-100 and apolipoprotein C-III, and incretin-based therapies, may enhance the treatment of postprandial lipemia, but their efficacy needs to be tested in clinical end point trials. Further work is required to develop a simple clinical protocol for investigating postprandial lipemia, as well as internationally agreed management guidelines for this type of dyslipidemia. |
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Authors:
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D C Chan; J Pang; G Romic; G F Watts |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 15 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 309 Citation Subset: IM |
Affiliation:
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Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia, dick.chan@uwa.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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