Document Detail


Postprandial hyperglycemia after a gastrectomy and the prediabetic state: a comparison between a distal and total gastrectomy.
MedLine Citation:
PMID:  18668310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Postprandial hyperglycemia is recognized as an important risk factor for developing type 2 diabetes; it is also common in patients after a gastrectomy and is likely to become exacerbated after a total gastrectomy rather than after a distal gastrectomy. In this study, we investigated the glucose and insulin responses after oral glucose tolerance test (OGTT), and compared the incidence of postchallenge hyperglycemia after OGTT in patients after a distal and total gastrectomy. METHODS: Forty-six patients, including 18 patients after a distal gastrectomy and 28 after a total gastrectomy, underwent a 75-g OGTT, and the plasma concentrations of glucose and insulin were measured after OGTT. RESULTS: Glucose peaked at 30 min in the distal gastrectomy patients and 60 min in the total gastrectomy patients, and there were significant differences in the 1-h plasma glucose (PG) and 1.5-h PG levels between the distal and total gastrectomy patients. Insulin peaked at 60 min in both the distal and total gastrectomy patients, and there were significant differences in insulin levels at 60 min between the distal and total gastrectomy patients. The incidence of postchallenge hyperglycemia in the patients after a total gastrectomy (57.1%) was higher than in those after distal gastrectomy (27.8%). Moreover, significant positive correlations were found between 1-h PG and hemoglobin antigen HbA1c after a total gastrectomy but not after a distal gastrectomy. CONCLUSIONS: These results suggest that postchallenge hyperglycemia after OGTT may become more exacerbated after a total gastrectomy than after a distal gastrectomy. Postprandial hyperglycemia, especially after a total gastrectomy, may therefore be involved in the development of diabetes.
Authors:
Hiroshi Yamamoto; Hiroshi Tsuchihashi; Hiroya Akabori; Hiroyuki Naitoh; Hiroshi Maegawa; Tohru Tani
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-07-31
Journal Detail:
Title:  Surgery today     Volume:  38     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-31     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  685-90     Citation Subset:  IM    
Affiliation:
Department of Surgery, Department of Medicine, Shiga University of Medical Science, Seta-tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Blood Glucose / analysis
Female
Gastrectomy / methods*
Glucose Tolerance Test
Humans
Hyperglycemia / blood,  etiology*
Insulin / blood
Linear Models
Male
Middle Aged
Postprandial Period*
Prediabetic State / blood,  etiology*
Risk Factors
Stomach Neoplasms / surgery
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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