| Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome. | |
| | |
MedLine Citation:
|
PMID: 18065576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition associated with obesity and with reproductive and metabolic dysfunction. Abnormalities in appetite regulation in PCOS patients may contribute to difficulties in weight management. OBJECTIVE: We aimed to examine appetite, appetite hormones, and ad libitum food consumption before and after weight loss in overweight women with and without PCOS. DESIGN: Overweight age- and weight-matched women with (n = 14) and without (n = 14) PCOS undertook an 8-wk energy-restricted diet (5185.3 +/- 141.6 kJ/d). At baseline and study end, subjects consumed a test meal (936 kJ; 25% of energy from protein, 9% from fat, and 67% from carbohydrate). Subjective appetite and circulating glucose, insulin, ghrelin, cholecystokinin, and peptide YY were assessed at 0, 15, 30, 45, 60, 90, 120, and 180 min. A mixed buffet lunch was then offered to assess ad libitum food intake. RESULTS: Weight loss (4.2 +/- 3.9 kg) did not differ significantly between the 2 groups. Women with PCOS had significantly (P = 0.023) lower ghrelin concentrations before and after weight loss than did women without PCOS. The degree of postprandial ghrelin suppression was lower at weeks 0 (P = 0.048) and 8 (P = 0.069) in women with PCOS than in women without PCOS. There were no significant differences between the 2 groups in appetite responses, buffet consumption, or fasting or postprandial peptide YY and cholecystokinin before or after weight loss. CONCLUSIONS: PCOS was associated with lower fasting ghrelin and a smaller postprandial ghrelin suppression both before and after weight loss but was not associated with other postprandial gut peptides, subjective satiety, or food intake. It is not clear whether appetite regulation is impaired in PCOS. |
| | |
Authors:
|
Lisa J Moran; Manny Noakes; Peter M Clifton; Gary A Wittert; Carel W Le Roux; Mohammed A Ghatei; Stephen R Bloom; Robert J Norman |
Related Documents
:
|
16112276 - Ghrelin, the same peptide for different functions: player or bystander? 10605906 - Peripheral and central mechanisms regulating food intake and macronutrient selection. 17693746 - Influence of ghrelin on food intake and energy homeostasis. 10650146 - Fos expression in feeding-related brain areas following intracerebroventricular adminis... 8053926 - Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat l... 11836116 - Formation of a fairly stable diazoate intermediate of 5-methyl-2'-deoxycytidine by hno2... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 86 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-12-10 Completed Date: 2008-01-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1603-10 Citation Subset: AIM; IM |
Affiliation:
|
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Appetite Regulation / physiology* Blood Glucose / metabolism Cholecystokinin / blood* Eating / physiology Female Ghrelin / blood* Homeostasis Humans Insulin / blood Motor Activity Overweight / diet therapy, metabolism* Peptide YY / blood* Polycystic Ovary Syndrome / blood*, diet therapy Postprandial Period Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Ghrelin; 106388-42-5/Peptide YY; 11061-68-0/Insulin; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel calcium-gelled, alginate-pectin beverage reduced energy intake in nondieting overweight and ob...
Next Document: Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects ...