Document Detail

Postprandial gallbladder motor function: refilling and turnover of bile in health and in cholelithiasis.
MedLine Citation:
PMID:  7615209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Impaired gallbladder emptying is implicated in gallstone disease. Ultrasonography and scintigraphy have shown conflicting results because the former is influenced by postprandial refilling, whereas the latter is not influenced by refilling. The aim of this study was to measure postprandial refilling and turnover of bile by combining the two techniques. METHODS: Simultaneous scintigraphy and ultrasonography were used in 14 patients with gallstones and 11 healthy controls. Measurements were performed while the patients were fasting and at 10-minute intervals after a standard meal for 90 minutes, and the measurements were used to calculate postprandial refilling, turnover of bile (in milliliters), and turnover index. RESULTS: Ultrasonography and scintigraphy provided different gallbladder emptying patterns. Compared with controls, patients with gallstones had impaired emptying by both scintigraphy (P < 0.0001) and ultrasonography (P < 0.01). Postprandial refilling and turnover were both reduced between 60 and 90 minutes (P < 0.05), and the turnover index was markedly reduced (1.8 vs. 3.5; P < 0.001). CONCLUSIONS: Simultaneous scintigraphy and ultrasonography provide a new model of gallbladder motor function showing that refilling begins immediately postprandially. In healthy controls, the gallbladder postprandially handles up to six times its basal volume within a period of 90 minutes, but this turnover of bile is markedly reduced in cholelithiasis causing a reduced washout effect of the gallbladder contents, including cholesterol crystals.
R P Jazrawi; P Pazzi; M L Petroni; N Prandini; C Paul; J A Adam; S Gullini; T C Northfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  109     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  582-91     Citation Subset:  AIM; IM    
Department of Medicine, St. George's Hospital Medical School, London, England.
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MeSH Terms
Analysis of Variance
Bile / metabolism*
Cholelithiasis / metabolism,  physiopathology*
Gallbladder / physiology*,  physiopathology,  radionuclide imaging,  ultrastructure
Reference Values

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