Document Detail

Postprandial effects of an oleic acid-rich oil compared with butter on clotting factor VII and fibrinolysis in healthy men.
MedLine Citation:
PMID:  9846847     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Factor VII coagulant activity (FVII:c) is associated with an increased risk of fatal ischemic heart disease, is correlated with plasma triacylglycerol concentration, and increases after a meal rich in long-chain fatty acids. OBJECTIVE: We planned to compare effects of meals rich in oleate and butter fat with those of a low-fat meal on FVII:c and fibrinolytic activity. DESIGN: A crossover design was used to compare the postprandial effects on coagulant and fibrinolytic activities in 12 men of 3 high-fat (95 g) meals--high oleate, butter, and oleate + medium-chain triacylglycerols (oleate+MCT)--with an isoenergetic low-fat meal (18 g MCT). The oleate+MCT blend was used to mimic the ratio of long-chain to shorter-chain fatty acids in butter. RESULTS: Neither the amount nor type of fat consumed influenced plasminogen activator inhibitor 1 or t-plasminogen activator activities or D-dimer concentration. FVII:c increased by 12.5% (95% CI: 4.6%, 20.5%) after the high-fat meals at 3 h and by 6.7% (95% CI: 1.6%, 11.7%) at 7 h and changed 7 h after the low-fat meal by -14.3% (95% CI: -3.3%, -25.4%). The responses to the high-fat meals did not differ. Measurements of activated FVII (FVIIa), FVII zymogen, and activated FXII (FXIIa) concentrations made after the low-fat and high-oleate meals showed a significant increase in FVIIa only after the high-oleate meal. CONCLUSIONS: The results of this study confirm that FVII:c falls after a low-fat meal and suggests that postprandial activation of FVII occurs rapidly after a fat-rich meal without involving an increase in FXIIa.
F R Oakley; T A Sanders; G J Miller
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  68     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1202-7     Citation Subset:  AIM; IM    
Nutrition, Food and Health Research Centre, King's College London, St Bartholomew's Hospital, United Kingdom.
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MeSH Terms
Cross-Over Studies
Diet, Fat-Restricted
Dietary Fats / administration & dosage*
Dietary Fats, Unsaturated / administration & dosage*
Factor VII / metabolism*
Factor XIIa / metabolism
Fibrin Fibrinogen Degradation Products / metabolism
Oleic Acid / administration & dosage*
Plasminogen Activator Inhibitor 1 / metabolism
Tissue Plasminogen Activator / metabolism
Triglycerides / blood
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fibrin Fibrinogen Degradation Products; 0/Plasminogen Activator Inhibitor 1; 0/Triglycerides; 0/fibrin fragment D; 112-80-1/Oleic Acid; 8029-34-3/Butter; 9001-25-6/Factor VII; EC XIIa; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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