Document Detail

Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men.
MedLine Citation:
PMID:  22955513     Owner:  NLM     Status:  MEDLINE    
Adverse effects on health mediated by increased plasma FFA concentrations are well established and older individuals are particularly susceptible to these effects. We sought to determine the effects of the amount of dietary fat on increasing the plasma FFA concentrations as a result of "spillover" of dietary fat into the plasma FFA pool during the postprandial period in older men. Healthy, older participants (63-71 y old) were studied in a randomized, crossover design following ingestions of low (LF) and moderate (MF) amounts of [1,1,1-(13)C]-triolein-labeled fat, corresponding to 0.4 and 0.7 g of fat/kg body weight, respectively. Spillover of dietary fatty acids into plasma during the 8-h postprandial period (AUC; mmol L(-1) h) after MF ingestion was 1.2 times greater than that after LF ingestion (2.8 ± 0.4 vs. 1.2 ± 0.1; P < 0.05). The spillover of dietary fatty acids following the MF, but not the LF, ingestion was correlated with the percent body fat (r(s) = -0.89) and percent body fat-free mass (r(s) = 0.94) of the men (P < 0.05). After adjusting to the amount of ingested fat, the spillover of dietary fatty acids in the MF trial was disproportionally higher than that in the LF trial (P < 0.05), but the corresponding postprandial plasma TG responses did not differ between trials. In conclusion, spillover of dietary lipid into plasma is disproportionally increased at higher doses of dietary fat and this response is inversely related to adiposity in healthy men of advanced age.
Guilherme M Puga; Christian Meyer; Lawrence J Mandarino; Christos S Katsanos
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-05
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2012-12-03     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1806-11     Citation Subset:  IM    
Center for Metabolic and Vascular Biology, Arizona State University/Mayo Clinic Arizona, Scottsdale, AZ, USA.
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MeSH Terms
Adiposity / physiology*
Chylomicrons / metabolism
Cross-Over Studies
Dietary Fats / administration & dosage*,  blood*
Eating / physiology*
Fatty Acids, Nonesterified / adverse effects,  blood
Insulin / blood
Lipid Metabolism / physiology
Middle Aged
Postprandial Period / physiology*
Risk Factors
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Triglycerides

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