Document Detail


Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men.
MedLine Citation:
PMID:  22955513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adverse effects on health mediated by increased plasma FFA concentrations are well established and older individuals are particularly susceptible to these effects. We sought to determine the effects of the amount of dietary fat on increasing the plasma FFA concentrations as a result of "spillover" of dietary fat into the plasma FFA pool during the postprandial period in older men. Healthy, older participants (63-71 y old) were studied in a randomized, crossover design following ingestions of low (LF) and moderate (MF) amounts of [1,1,1-(13)C]-triolein-labeled fat, corresponding to 0.4 and 0.7 g of fat/kg body weight, respectively. Spillover of dietary fatty acids into plasma during the 8-h postprandial period (AUC; mmol L(-1) h) after MF ingestion was 1.2 times greater than that after LF ingestion (2.8 ± 0.4 vs. 1.2 ± 0.1; P < 0.05). The spillover of dietary fatty acids following the MF, but not the LF, ingestion was correlated with the percent body fat (r(s) = -0.89) and percent body fat-free mass (r(s) = 0.94) of the men (P < 0.05). After adjusting to the amount of ingested fat, the spillover of dietary fatty acids in the MF trial was disproportionally higher than that in the LF trial (P < 0.05), but the corresponding postprandial plasma TG responses did not differ between trials. In conclusion, spillover of dietary lipid into plasma is disproportionally increased at higher doses of dietary fat and this response is inversely related to adiposity in healthy men of advanced age.
Authors:
Guilherme M Puga; Christian Meyer; Lawrence J Mandarino; Christos S Katsanos
Related Documents :
16033203 - Changes in succinate dehydrogenase activity in various parts of the brain during combin...
24345973 - Autonomic modulation and its relation with body composition in swimmers.
22251263 - Absolute and relative organ weight trends in b6c3f1 mice.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-05
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2012-12-03     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1806-11     Citation Subset:  IM    
Affiliation:
Center for Metabolic and Vascular Biology, Arizona State University/Mayo Clinic Arizona, Scottsdale, AZ, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adiposity / physiology*
Aged
Chylomicrons / metabolism
Cross-Over Studies
Dietary Fats / administration & dosage*,  blood*
Eating / physiology*
Fatty Acids, Nonesterified / adverse effects,  blood
Humans
Insulin / blood
Lipid Metabolism / physiology
Male
Middle Aged
Postprandial Period / physiology*
Risk Factors
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
R21DK082820/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Triglycerides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men ...
Next Document:  Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults.